dict.md logo
Choose languages of interest
SELECT >>
English
Advertisement:
Translation
 
0 translations
 
Definition
 
enEnglish
MSC Gene definition: This gene is involved in the repression of transcription. It may also play a role in the regulation of B-cell differentiation.
Musculin definition: The predicted 218-amino acid protein contains a bHLH motif, a putative nuclear localization signal, a glycine-rich region, and a stretch of acidic residues. MSC is capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro, and forms heterodimers with E2A proteins in vivo. MSC contains a transcriptional repression domain and is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. MSC is a downstream target of the B-cell receptor signal transduction pathway. Mice engineered to lack the protein lack muscle structures derived from the first brachial arch. (from LocusLink and OMIM)
 
Examples
 
0 examples
 
Publications
 
0 publications