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Neuregulin 2 definition: Encoded by human NRG2 Gene (NRG Family), variant type I membrane or soluble growth factor Neuregulin 2 proteins (422-858-aa, 91.7-kD precursor) contain an N-terminal domain, an Ig-C2 loop, an EGF-like domain, a transmembrane sequence, and a large cytoplasmic tail with potential N-linked and O-linked glycosylation sites. The membrane-bound form seems to be inactive and the cytoplasmic domain may regulate trafficking and proteolytic processing (by dimerization). Like Neuregulin 1, Neuregulin 2 binds to transmembrane ERBB3 and ERBB4 tyrosine kinase receptors, recruits ERBB1 and ERBB2 coreceptors, and induces receptor activation. ERBB receptor binding may involve entirely the EGF-like domain. Found primarily in the nervous system, Neuregulin 2 induces growth and differentiation of epithelial, neuronal, glial, and other cell types. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Neuregulin 2 definition: Neuregulin-2, a novel neuregulin-1-like molecule encoded by a distinct gene. Like neuregulin-1, neuregulin-2 also binds to ErbB3 and ErbB4, although it appears to signal distinctly, perhaps by activating different receptor heterodimers. Neuregulin-2 is primarily found in granule cells in the cerebellum, hippocampus, and olfactory bulb.
Neuregulin-1 definition: A peptide factor originally identified by its ability to stimulate the phosphorylation the erbB-2 receptor (RECEPTOR, ERBB-2). It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Variant forms of NEUREGULIN-1 occur through alternative splicing of its mRNA.
Neuregulin 1 definition: Neuregulin-1 was first cloned as "heregulin" and "neu differentiation factor" and was initially thought to be a ligand for ErbB2, which is overexpressed in about 25% of women with breast cancer. Neuregulin-1 has also been studied as the "glial growth factor," which acts as a Schwann cell mitogen, and as "ARIA" (acetylcholine receptor inducing activity), a regulator of the expression of acetylcholine receptors.
NRG2 Gene definition: This gene is involved in cellular differentiation, growth and proliferation.
NRG1 Gene definition: This gene plays a role in cellular differentiation, growth and proliferation.
NRG1 wt Allele definition: Human NRG1 wild-type allele is located within 8p21-p12 and is approximately 1,124 kb in length. This allele, which encodes pro-neuregulin-1, membrane-bound isoform protein, is involved in the compositional regulation of neurotransmitter receptors in maturing synapses in the brain, proliferation and differentiation.
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