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Cytochrome P-450 CYP2E1 definition: An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include alcohol; NITROSAMINES; BENZENE; URETHANE; and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
Cytochrome P450 2E1 definition: Cytochrome P450 2E1 (493 aa, ~57 kDa) is encoded by the human CYP2E1 gene. This protein plays a role in the both the metabolism of drugs, ethanol and other xenobiotics and the oxidative activation of nitrosamines.
Dimethylnitrosamine definition: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.
N-Nitrosodimethylamine definition: A volatile, combustible, yellow, oily liquid nitrosamine with a faint characteristic odor that decomposes when exposed to light and emits toxic fumes of nitrogen oxides when heated to decomposition. N-Nitrosodimethylamine is primarily used in laboratory research to induce tumors in experimental animals. This substance may be formed during the cooking of foods, especially cured meats and fish, that contain sodium nitrite as a preservative, but is also found in several vegetables, cheeses, alcoholic beverages and fruits, and as a contaminant in rubber products. Exposure to NNitrosodimethylamine irritates the skin and eyes and damages the liver. This substance is reasonably anticipated to be a human carcinogen. (NCI05)
dimethylnitrosamine demethylase activity definition: Catalysis of the removal of a methyl group from N-nitrosodimethylamine. [GOC:mah]
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