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However, another Notch ligand, JAG1, is expressed early in the sensory patches prior to cell differentiation, indicating that there may be an earlier role for Notch signaling in sensory development in the ear.

Amy E Kiernan et al.

PLoS Genetics 2 (1), 01 Jan 2006

Citation: Kiernan AE, Xu J, Gridley T (2006) The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear.

Amy E Kiernan et al.

PLoS Genetics 2 (1), 01 Jan 2006

Discussion We have demonstrated that Notch signaling, mediated by the JAG1 ligand, is required early in development for the formation of the sensory regions of the ear.

Amy E Kiernan et al.

PLoS Genetics 2 (1), 01 Jan 2006

One possibility is that another Notch ligand is compensating for the loss of JAG1 function.

Amy E Kiernan et al.

PLoS Genetics 2 (1), 01 Jan 2006

539 566 Lewis J 1991 Rules for the production of sensory cells Ciba Found Symp 160 25 53 1752167 Adam J Myat A Le Roux I Eddison M Henrique D 1998 Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: Parallels with Drosophila sense-organ development Development 125 4645 4654 9806914 Eddison M Le Roux I Lewis J 2000 Notch signaling in the development of the inner ear: Lessons from Drosophila Proc Natl Acad Sci U S A 97 11692 11699 11050197 Parks AL Huppert SS Muskavitch MA 1997 The dynamics of neurogenic signalling underlying bristle development in Drosophila melanogaster Mech Dev 63 61 74 9178257 Bray S 1998 Notch signalling in Drosophila: Three ways to use a pathway Semin Cell Dev Biol 9 591 597 10075488 Lai EC 2004 Notch signaling: Control of cell communication and cell fate Development 131 965 973 14973298 Haddon C Jiang YJ Smithers L Lewis J 1998 Delta-Notch signalling and the patterning of sensory cell differentiation in the zebrafish ear: Evidence from the mind bomb mutant Development 125 4637 4644 9806913 Lanford PJ Lan Y Jiang R Lindsell C Weinmaster G 1999 Notch signalling pathway mediates hair cell development in mammalian cochlea Nat Genet 21 289 292 10080181 Riley BB Chiang M Farmer L Heck R 1999 The deltaA gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is regulated by pax2.1 Development 126 5669 5678 10572043 Zhang N Martin GV Kelley MW Gridley T 2000 A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea Curr Biol 10 659 662 10837254 Zine A Aubert A Qiu J Therianos S Guillemot F 2001 Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear J Neurosci 21 4712 4720 11425898 Daudet N Lewis J 2005 Two contrasting roles for Notch activity in chick inner ear development: Specification of prosensory patches and lateral inhibition of hair-cell differentiation Development 132 541 551 15634704 Kiernan AE Cordes R Kopan R Gossler A Gridley T 2005 The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear Development 132 4353 4362 16141228 Fekete DM Muthukumar S Karagogeos D 1998 Hair cells and supporting cells share a common progenitor in the avian inner ear J Neurosci 18 7811 7821 9742150 Baron M 2003 An overview of the Notch signalling pathway Semin Cell Dev Biol 14 113 119 12651094 Gridley T 2003 Notch signaling and inherited disease syndromes Hum Mol Genet 12 (Spec No 1) R9 R13 12668592 Schweisguth F 2004 Notch signaling activity Curr Biol 14 R129 138 14986688 Morrison A Hodgetts C Gossler A Hrabe de Angelis M Lewis J 1999 Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear Mech Dev 84 169 172 10473135 Bermingham NA Hassan BA Price SD Vollrath MA Ben-Arie N 1999 Math1: An essential gene for the generation of inner ear hair cells Science 284 1837 1841 10364557 Chen P Johnson JE Zoghbi HY Segil N 2002 The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination Development 129 2495 2505 11973280 Zheng JL Gao WQ 2000 Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears Nat Neurosci 3 580 586 10816314 Woods C Montcouquiol M Kelley MW 2004 Math1 regulates development of the sensory epithelium in the mammalian cochlea Nat Neurosci 7 1310 1318 15543141 Kiernan AE Pelling AL Leung KK Tang AS Bell DM 2005 Sox2 is required for sensory organ development in the mammalian inner ear Nature 434 1031 1035 15846349 Buescher M Hing FS Chia W 2002 Formation of neuroblasts in the embryonic central nervous system of Drosophila melanogaster is controlled by SoxNeuro Development 129 4193 4203 12183372 Overton PM Meadows LA Urban J Russell S 2002 Evidence for differential and redundant function of the Sox genes Dichaete and SoxN during CNS development in Drosophila Development 129 4219 4228 12183374 Kiernan AE Ahituv N Fuchs H Balling R Avraham KB 2001 The Notch ligand Jagged1 is required for inner ear sensory development Proc Natl Acad Sci U S A 98 3873 3878 11259677 Tsai H Hardisty RE Rhodes C Kiernan AE Roby P 2001 The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti Hum Mol Genet 10 507 512 11181574 Hebert JM McConnell SK 2000 Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures Dev Biol 222 296 306 10837119 Pirvola U Ylikoski J Trokovic R Hebert JM McConnell SK 2002 FGFR1 is required for the development of the auditory sensory epithelium Neuron 35 671 680 12194867 Tax FE Yeargers JJ Thomas JH 1994 Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila Nature 368 150 154 8139658 Shimizu K Chiba S Kumano K Hosoya N Takahashi T 1999 Mouse jagged1 physically interacts with notch2 and other notch receptors.

Amy E Kiernan et al.

PLoS Genetics 2 (1), 01 Jan 2006

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