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Dihydroorotase definition: An enzyme that, in the course of pyrimidine biosynthesis, catalyzes ring closure by removal of water from N-carbamoylaspartate to yield dihydro-orotic acid. EC 3.5.2.3.
Dihydroorotate Oxidase definition: An enzyme that in the course of pyrimidine biosynthesis, catalyzes the oxidation of dihydro-orotic acid to orotic acid utilizing oxygen as the electron acceptor. This enzyme is a flavoprotein which contains both FLAVIN-ADENINE DINUCLEOTIDE and FLAVIN MONONUCLEOTIDE as well as iron-sulfur centers. EC 1.3.3.1.
Orotate Phosphoribosyltransferase definition: The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.
Dihydroorotate Dehydrogenase definition: A flavoprotein (FAD, FMN). Catalyzes the reaction of S-dihydroorotate and oxygen into orotate and hydrogen peroxide. Ferricyanide can act as acceptor. [EC 1.3.3.1 created 1961] (from IUBMB)
Dihydroorotate Dehydrogenase definition: A drug target in the pyrimidine biosynthetic pathway. Variation in gene expression or sequence may alter the efficacy of chemotherapy.
orotate definition: the 4-carboxylate derivative of uracil, a metabolic intermediate.
orotic aciduria definition: excess of orotic acid in the urine occurring in several metabolic disorders and also resulting from the administration of some drugs; one disorder is an autosomal recessive defect of pyrimidine metabolism due to deficiency of orate phosphoribosyltransferate or orotidine 5'-phosphatae decarboxylase.
orotate reductase (NADH) activity definition: Catalysis of the reaction: (S)-dihydroorotate + NAD+ = orotate + NADH + H+. [EC:1.3.1.14]
orotate phosphoribosyltransferase activity definition: Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.10]
orotate reductase (NADPH) activity definition: Catalysis of the reaction: (S)-dihydroorotate + NADP+ = orotate + NADPH. [EC:1.3.1.15, MetaCyc:OROTATE-REDUCTASE-(NADPH)-RXN]
 
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