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The expression of the transgene resulted in the development of a transgenic mouse whose phenotype and orotic acid excretion are fully normalized.

C Cavard et al.

Nucleic Acids Research 16 (5 Pt B), 25 Mar 1988

More direct genetic selection of diploids on -TRP-LYS synthetic media in the presence of 5-fluoro-orotic acid (5-FOA), led to the isolation of mitotic recombinant YACs at a high frequency.

F Rotomondo et al.

Nucleic Acids Research 22 (7), 11 Apr 1994

The expression of thymidylate synthase, orotic acid phosphoribosyltransferase and dihydropyrimidine dehydrogenase, which are well known to be related to drug resistance, differed among these cell lines, indicating that these cell lines acquired different resistance mechanisms.

Jun Hamaguchi et al.

Molecular Cancer 6 (7), 21 Sep 2007

5-FU metabolic enzymes, such as thymidylate synthase (TS), orotic acid phosphoribosyltransferase (OPRT), uridine phosphorylase (UP), dihydropyrimidine dehydrogenase (DPD), and pyrimidine nucleoside phosphorylase (PyNPase), are thought to play a role in the resistance mechanism [ 5 - 8 ].

Jun Hamaguchi et al.

Molecular Cancer 6 (7), 21 Sep 2007

Abbreviations CD-DST- Collagen gel droplet-embedded culture drug sensitivity test; DPD- Dihydropyrimidine dehydrogenase; 5-FU- 5-fluorouracil; Fuc- Fucose; Gal- Galactose; Glc- Glucose; GlcNAc- N-acetylglucosamine; HPLC- High-performance liquid chromatography; IC-50- 50% inhibition concentration; Man- Mannose; MTT- Mossman's Abbreviations CD-DST- Collagen gel droplet-embedd-ed culture drug sensitivity test; DPD- Dihydropyr-imidine dehydrogenase; 5-FU- 5-fluorouracil; Fuc-- Fucose; Gal- Galactose; Glc- Glucose; GlcNAc-- N-acetylglucosamine; HPLC- High-performance liqu-id chromatography; IC-50- 50% inhibition concentr-ation; Man- Mannose; MTT- Mossman's 3-(4,5-Dime-thyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium brom-ide; ODS- Octadecylsilyl; OPRT- Orotic acid phos-phoribosyltransferase; bromide; ODS- Octadecylsilyl; OPRT- Orotic acid phosphoribosyltransferase;

Jun Hamaguchi et al.

Molecular Cancer 6 (7), 21 Sep 2007

 
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