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PTGS2 Gene definition: This gene is involved in mitogenesis, inflammation and angiogenesis.
Prostaglandin-Endoperoxide Synthase 2 definition: Encoded by cytokine/mitogen-induced human PGHS2 Gene (PGHS Family), homodimeric microsomal membrane 604-aa 69-kD (precursor) Prostaglandin-Endoperoxide Synthase 2, with 1 EGF-like domain and 86-89% identity to mammalian PTGS2 proteins, is involved in prostanoid-induced inflammation and mitogenesis. A target of NSAIDs, rate-limiting PGHS2 dioxygenase and peroxidase activity converts arachidonate to prostaglandins and thromboxanes. COX2 induction stimulates peripheral nociceptors. Deregulated expression may enhance carcinogenic potential; weak expression in pheochromocytomas favors benign diagnosis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Prostaglandin-Endoperoxide Synthase 2 definition: A rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins, COX-2 is expressed in cells involved in inflammatory processes and has been implicated in tumor promotion as well as a negative prognosis. COX-2 is expressed in 50% of pancreatic tumors. Anti-inflammatory glucocorticoids are potent inhibitors of cyclooxygenase. Inhibition or lack of COX-2 reduces tumor growth and blocks angiogenesis. Aspirin and etodolac, both COX-2 inhibitors, inhibit growth of pancreatic cancer cell lines. (from Cancer 2001. 91:333, Medscape, OMIM 600262, and NCI)
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