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P-Glycoprotein definition: A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
P glycoprotein definition: gene product of the multidrug resistance gene mdr-1, believed to be a membrane spanning transporter that can pump a wide variety of cytotoxic agents out of the cell.
ATP-Binding Cassette, Sub-Family B, Member 1 definition: Human p-glycoprotein-1 (1280 aa, 141 kDa) is encoded by the human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) gene. The protein is an ATP-dependent, transmembrane transport/efflux pump glycoprotein that is expressed in liver, kidney, small intestine and brain.
 
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Publications
 

Diversity of the Brain Dystrophin-Glycoprotein Complex

Kevin Culligan et al.

Journal of Biomedicine and Biotechnology , 2002

Ivermectin: does P-glycoprotein play a role in neurotoxicity?

Geoffrey Edwards

Filaria Journal , 24 Oct 2003

Identification of the hASCT2-binding domain of the Env ERVWE1/syncytin-1 fusogenic glycoprotein

Valérie Cheynet et al.

Retrovirology , 04 Jul 2006

3,3′,4,4′,5-Pentachlorobiphenyl Inhibits Drug Efflux Through P-Glycoprotein in KB-3 Cells Expressing Mutant Human P-Glycoprotein

Hiroshi Fujise et al.

Journal of Biomedicine and Biotechnology , 29 Jul 2004

MLC1 is associated with the Dystrophin-Glycoprotein Complex at astrocytic endfeet

Ilja Boor et al.

Acta Neuropathologica , 01 Oct 2007

Platelet glycoprotein IIb/IIIa receptor blockade in coronary artery disease

Jassim Al Suwaidi et al.

Current Controlled Trials in Cardiovascular Medicine , 2001

Astroglial expression of the P-glycoprotein is controlled by intracellular CNTF

Christelle Monville et al.

BMC Cell Biology , 31 Jul 2002

Alternative promoter usage of the membrane glycoprotein CD36

Malin Andersen et al.

BMC Molecular Biology , 03 Mar 2006

Role of p-glycoprotein expression in predicting response to neoadjuvant chemotherapy in breast cancer-a prospective clinical study

Chintamani et al.

World Journal of Surgical Oncology , 14 Sep 2005

beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones

Eyleen LK Goh et al.

Molecular Brain , 15 Oct 2008

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