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Myeloblastin definition: A polymorphonuclear leukocyte-derived serine protease that degrades proteins such as ELASTIN; FIBRONECTIN; LAMININ; VITRONECTIN; and COLLAGEN. It is named for its ability to control myeloid cell growth and differentiation.
Proteinase 3 definition: Encoded by human PRTN3 Gene (Peptidase S1 Family), 256-aa 29-kD Proteinase 3 precursor is coordinately expressed with and packed in neutrophilic azurophil granules with ELA2 and AZU during myeloid development. An antibiotic neutral serine protease, PRTN3 appears to degrade elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV by preferential cleavage at Ala-X and Val-X bonds. (from LocusLink, Swiss-Prot, OMIM, and NCI)
PRTN3 Gene definition: This gene plays a role in the growth of hematopoietic cells.
PRTN3 wt Allele definition: Human PRTN3 wild-type allele is located in the vicinity of 19p13.3 and is approximately 7 kb in length. This allele, which encodes myeloblastin protein, plays a role in the induction of factor-independent growth of hematopoietic cells. Overexpression of the PRTN3 gene is associated with Wegener granulomatosis.
 
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