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PTB-Bescheinigung Letter of Conformity
Polypyrimidine Tract-Binding Protein definition: A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.
Splicing Factor Proline-and Glutamine-Rich definition: Splicing factor, proline- and glutamine-rich protein (707 aa, ~76 kDa) is encoded by the human SFPQ gene. This protein may be involved in messenger RNA processing, transcriptional regulation and the modulation of DNA secondary structure.
SFPQ Gene definition: This gene may be involved in both transcriptional regulation and nuclear RNA processing.
PTB Domain definition: Phosphotyrosine binding (PTB) domains are 100-150 residue modules that commonly bind Asn-Pro-X-Tyr motifs. The PTB domains of the docking proteins Shc and IRS-1 require ligand phosphorylation on the tyrosine residue (NPXpY) for binding. More N-terminal sequences are also required for high affinity binding and conferring specificity. The peptide binds as a b-strand to an anti-parallel b-sheet, while the NPXpY motif makes a turn, positioning the pY for recognition by basic residues. The PTB domains of proteins such as X11, Dab, Fe65 and Numb apparently recognize NPXY or related peptide motifs, but are not dependent on ligand phosphorylation. In addition, the Numb PTB domain can bind an unrelated peptide that forms a helical turn.
PTB domain binding definition: Interacting selectively with a phosphotyrosine-binding (PTB) domain of a protein. [Pfam:PF02174.5, PMID:15924411]
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