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Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide definition: Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide, encoded by the PIK3CG gene, belongs to the PI3/PI4-kinase family of proteins. This protein is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. (from LocusLink)
 
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