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Platelet Activating Factor definition: A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.
platelet activating factor definition: produced in response to specific stimuli by a variety of cell types, including neutrophils, basophils, platelets, and endothelial cells; several molecular species of platelet activating factor have been identified which vary in the length of the O-alkyl side chain; an important mediator of bronchoconstriction.
1-Alkyl-2-acetylglycerophosphocholine Esterase definition: A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.
platelet activating factor receptor activity definition: Combining with platelet activating factor to initiate a change in cell activity. [GOC:mah]
platelet activating factor biosynthetic process definition: The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. [ISBN:0198547684]
platelet activating factor metabolic process definition: The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. [ISBN:0198547684]
1-alkyl-2-acetylglycerophosphocholine esterase complex definition: An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF). [GOC:jl, PMID:10542206, UniProtKB:Q28017]
platelet-activating factor acetyltransferase activity definition: Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid. [EC:2.3.1.149, MetaCyc:2.3.1.149-RXN]
PAFAH1B1 Gene definition: This gene is involved in the modulation of neuronal migration.
Platelet Activating Factor Activation definition: By decreased degradation, or increased production or receptor binding, Platelet Activating Factor Activation involves induction of the activity of a phospholipid derivative (platelet activating factor) formed by platelets, basophils, neutrophils, monocytes, and macrophages that acts as a potent agent of platelet aggregation, inflammation, neutrophil activity, prostaglandin synthesis, and systemic anaphylaxis: hypotension, thrombocytopenia, neutropenia, and bronchoconstriction.
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Examples
 

Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic asthma.

Rene Schmidt et al.

Journal of Occupational Medicine and Toxicology (London, England) 3 (7), 20 Feb 2008

Therefore, the aim of this study was to evaluate the effects of montelukast on platelet activating factor- and tachykinin induced tracheal secretory activity.

Rene Schmidt et al.

Journal of Occupational Medicine and Toxicology (London, England) 3 (7), 20 Feb 2008

The effects of montelukast on platelet activating factor- and tachykinin induced tracheal secretory activity in the rat were assessed by quantification of secreted 35 SO 4 labelled mucus macromolecules using the modified Ussing chamber technique.

Rene Schmidt et al.

Journal of Occupational Medicine and Toxicology (London, England) 3 (7), 20 Feb 2008

Platelet activating factor potently stimulated airway secretion, which was completely inhibited by the platelet activating factor receptor antagonist WEB 2086 and montelukast.

Rene Schmidt et al.

Journal of Occupational Medicine and Toxicology (London, England) 3 (7), 20 Feb 2008

Cys-leukotriene-1 receptor antagonism by montelukast reverses the secretagogue properties of platelet activating factor to the same degree as the specific platelet activating factor antagonist WEB 2086 but has no influence on treacheal secretion elicited by tachykinins.

Rene Schmidt et al.

Journal of Occupational Medicine and Toxicology (London, England) 3 (7), 20 Feb 2008

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