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Protein Phosphatase 2 Regulatory Subunit B Beta definition: Ubiquitously expressed (highest in brain) as 2 isoforms by human PPP2R5B Gene (PP2A Subunit B Family), serine phosphorylated cytoplasmic Protein Phosphatase 2 Regulatory Subunit B Beta is a regulatory subunit of PP2A. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)
PPP2R5B Gene definition: This gene plays a role in the negative control of cell growth and division.
PPP2R5B wt Allele definition: Human PPP2R5B wild-type allele is located within 11q12-q13 and is approximately 10 kb in length. This allele, which encodes serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform protein, is involved in modulating both the substrate selectivity and catalytic activity of the core protein phosphatase 2A heterodimer.
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