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PPP2R5E Gene definition: This gene plays a role in the negative control of cell growth and division.
Protein Phosphatase 2 Regulatory Subunit B Epsilon definition: Encoded as two isoforms by human PPP2R5E Gene (Phosphatase 2A Regulatory Subunit B Family), serine phosphorylated 55-kD Protein Phosphatase 2 Regulatory Subunit B Epsilon is a regulatory subunit of PP2A. PPP2R5E is predominantly concentrated in the perinuclear cytoplasm and excluded from the nucleus. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)
PPP2R5E wt Allele definition: Human PPP2R5E wild-type allele is located in the vicinity of 14q23.1 and is approximately 169 kb in length. This allele, which encodes serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform protein, plays a role in modulating both the substrate selectivity and catalytic activity of the core protein phosphatase 2A heterodimer.
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