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Non-Receptor Protein Tyrosine Phosphatase Gene definition: Non-Receptor Protein Tyrosine Phosphatase Genes encode Non-Receptor Protein Tyrosine Phosphatases, one of the two main categories (soluble and transmembrane receptor) of enzymes that catalyze removal of a tyrosine-attached phosphate group and are important in control of cell growth, proliferation, differentiation, and transformation. Two cysteines in the catalytic domain (one absolutely required for activity) are generally conserved; other conserved residues in the vicinity are important. (NCI)
Protein Phosphatase Gene definition: Protein Phosphatase Genes encode Protein Phosphatases, enzymes that remove tyrosine-, serine-, or threonine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase or a serine/threonine kinase. (NCI)
Protein Serine/Threonine Phosphatase Gene definition: Protein Serine/Threonine Phosphatase Genes encode Protein Serine/Threonine Phosphatases, a group of enzymes that specifically dephosphorylate phosphoserine and phosphothreonine residues in specific target proteins. Together with serine/threonine protein kinases, these enzymes regulate serine and threonine phosphorylation and dephosphorylation of target proteins in cellular signal transduction pathways typically involved in cell growth control. (NCI)
Protein Tyrosine Phosphatase Gene definition: Protein Tyrosine Phosphatase Genes encode Protein Tyrosine Phosphatases, enzymes that specifically remove tyrosine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase. Together with protein tyrosine kinases, Tyrosine Phosphatases regulate tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. (NCI)
DUSP1 wt Allele definition: Human DUSP1 wild-type allele is located within 5q34 and is approximately 3 kb in length. This allele, which encodes dual specificity protein phosphatase 1 protein, is involved in the dephosphorylation of both protein tyrosine phosphates and phosphoproteins. Decreased expression of the DUSP1 gene is associated with ovarian cancer.
 
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