dict.md logo
Choose languages of interest
SELECT >>
English
Advertisement:
Translation
 
0 translations
 
Definition
 
enEnglish
Peptide Hydrolases definition: Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.
proteolytic enzymes definition: Enzymes produced and secreted by the pancreas which aid in the proteolysis of proteins in the digestive tract. Pancreatic proteolytic enzymes include trypsin, chymotrypsin and carboxypeptidase; these enzymes are secreted as zymogens, inactive precursors of the enzymes, and are activated in the lumen of the digestive canal. Another proteolytic enzyme, enteropeptidase, is associated with the brush border of enterocytes; this enzyme catalyses the conversion of trypsinogen into trypsin which, in turn, can activate a number of other pancreatic zymogens. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43492&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43492&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38728" NCI Thesaurus)
Proteolytic Enzymes definition: Enzymes produced and secreted by the pancreas which aid in the proteolysis of proteins in the digestive tract. Pancreatic proteolytic enzymes include trypsin, chymotrypsin and carboxypeptidase; these enzymes are secreted as zymogens, inactive precursors of the enzymes, and are activated in the lumen of the digestive canal. Another proteolytic enzyme, enteropeptidase, is associated with the brush border of enterocytes; this enzyme catalyses the conversion of trypsinogen into trypsin which, in turn, can activate a number of other pancreatic zymogens. (NCI04)
Serine Endopeptidases definition: Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.
Serine Protease definition: Proteases that have a serine residue in the active center of the enzyme. These enzymes catalyze the hydrolysis of covalent peptidic bonds by serine nucleophilic attack. Serine proteases participate in a wide range of functions in the body, including blood clotting, inflammation, and digestion.
TNF Alpha ICE Proteinases definition: Tightly regulated and activated by proteolysis, TNF Alpha ICE Proteinases (ICE/CED3/Caspase Family, MEROPS C14 Peptidase Family) are Cysteine-dependent ASPartyl-specific proteASE (Caspases) effectors (active alpha2/beta2-tetrameric enzymes) of the extrinsic apoptosis cascade, induced by TNF cytokine stimulation of cell surface TNF receptors. By promoting a death-inducing signaling complex (DISC) between recruited FADD and caspase-8, activated receptors transmit signal to the cytoplasm and caspase-8 activation initiates an apoptosis cascade involving caspases 3, 4, 6, 7, 9 and 10 that destroys the cell by disintegrating its contents, including its DNA. The Caspase Family includes Caspases 1-14, ced-3 and Drosophila Ice.
Aspartic Acid Proteases definition: A subclass of peptide hydrolases that depend on an ASPARTIC ACID residue for their activity.
Aspartyl Protease definition: Aspartyl Proteases (Aspartic Endopeptidases) have an acidic residue (aspartate) involved in the catalytic process, have a pH optimum below 5 and catalyze the cleavage of internal peptide bonds in a polypeptide or protein.
Cysteine Proteases definition: A subclass of peptide hydrolases that depend on a CYSTEINE residue for their activity.
Cysteine Proteinase definition: An enzyme that contains an unpaired cysteine in the active site which acts as a nucleophilic thiol to catalyze the proteolytic processing of other proteins or polypeptides.
1 further definition >>