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Fusion Proteins, bcr-abl definition: Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. The p210(bcr-abl) fusion protein is found in patients with LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE. The p190(bcr-abl) fusion protein is found in patients with PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA. The activation of human c-abl by chromosomal translocation is essentially the same as the activation of murine c-abl by viral translocation in ABELSON MURINE LEUKEMIA VIRUS.
BCR-ABL Oncoprotein definition: An onco-protein generated from the fusion of Bcr and Abl genes by translocation process between chromosome 9 and 22 (Philadelphia chromosome), in CML (P210) and some ALL (P190). Aberrant expression of BCR-ABL in bone marrow cells results in a variety of leukemias.
 
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