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RRAS2 Gene definition: This gene is involved in signal transduction and intracellular protein transport.
RAS-Related Protein R-RAS2 definition: Encoded by human RRAS2 Gene (RAS GTPase Family), ubiquitous 204-aa 23-kDa RAS-Related Protein R-RAS2 is a plasma membrane-associated GTP-binding GTPase that may transduce growth inhibitory signals by exerting an antagonistic effect on a RAS effector. RRAS2 may be posttranslationally modified by palmitoylation and polyisoprenylation. Attachment to the inner surface of plasma membrane may require acylation of a C-terminal cysteine. RRAS2 defects can cause ovarian tumors. (NCI)
RRAS2 wt Allele definition: Human RRAS2 wild-type allele is located in the vicinity of 11p15.2 and is approximately 80 kb in length. This allele, which encodes Ras-related protein R-Ras2, may play a role in both phosphatidylinositol-mediated signal transduction and nuclear factor kappa B complex pathway attenuation. A point mutation in the gene is associated with ovarian cancer.
 
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