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Ras Protein Specific Guanine Nucleotide Releasing Factor 1 definition: The protein is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested, that the Ras-GEF activity of this protein in brain, can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
ras-GRF1 definition: A guanine nucleotide exchange factor that is expressed primarily in neuronal tissue and may be specific for the Ha-ras homolog of the RAS PROTEINS.
RASGRF1 wt Allele definition: Human RASGRF1 wild type allele is located in the vicinity of 15q24 and is approximately 129 kb in length. This allele, which encodes guanine nucleotide-releasing protein, is involved in the modulation of Ras signaling pathways.
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