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SPO11 Gene definition: This gene plays a role in meiotic recombination and centromere association.
SPO11 Meiotic Protein Covalently Bound to DSB-Like definition: SPO11 Meiotic Protein Covalently Bound to DSB-Like (SPO11), a protein encoded by the Spo11 gene, belongs to the TOP6A family. Meiotic recombination and proper segregation of chromosomes are initiated by the formation of double-strand breaks (DSBs) in paired homologs. Located in the nucleus, SPO11 is required for meiotic DSB formation and is covalently linked to the 5-prime end of DSBs during meiosis. SPO11 mediates DNA cleavage with assistance from a large number of other proteins, by a topoisomerase-like transesterase mechanism. SPO11 is highly expressed in testis. Two isoforms, 1 and 2, may be produced by alternative splicing. (NCI)
SPO11 wt Allele definition: Human SPO11 wild-type allele is located within 20q13.2-q13.3 and is approximately 14 kb in length. This allele, which encodes meiotic recombination protein SPO11, plays a role in both meiotic recombination and chromosomal segregation.
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