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sodium thiosulfate definition: A water soluble salt and reducing agent that reacts with oxidizing agents. Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion. In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity related to nitrogen mustard extravasation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39602&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39602&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1230" NCI Thesaurus)
Sodium Thiosulfate definition: A water soluble salt and reducing agent that reacts with oxidizing agents. Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion. In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity related to nitrogen mustard extravasation. (NCI04)
Sequence Tagged Sites definition: Short tracts of DNA sequence that are used as landmarks in GENOME mapping. In most instances, 200 to 500 base pairs of sequence define a Sequence Tagged Site (STS) that is operationally unique in the human genome (i.e., can be specifically detected by the polymerase chain reaction in the presence of all other genomic sequences). The overwhelming advantage of STSs over mapping landmarks defined in other ways is that the means of testing for the presence of a particular STS can be completely described as information in a database.
sequence tagged site definition: short, single-copy, genomic DNA sequences spaced at intervals of about 100 kb, used as landmarks to identify the physical origin (chromosomal position) of any clone (gene) of interest; touted as the new "lingua franca" of genome mapping.
Sequence Tagged Site definition: Short (200 to 500 base pairs) DNA sequence that is operationally unique and has a single occurrence in the human genome and whose location and base sequence are known and therefore they can be used as landmarks in genome mapping.
Adult Soft Tissue Sarcoma definition: Soft tissue sarcoma occuring in adults.
Childhood Soft Tissue Sarcoma definition: Soft tissue sarcoma occuring in childhood.
STS Gene definition: This gene plays a role in synthesis of steroids during pregnancy.
YAC-Based STS-Content Mapping definition: YAC based content mapping is a clone-based physical genome mapping strategy. Content mapping is done by ordering sequence tagged sites (STS), regions of the genome which can be uniquely identified, and YAC (Yeast Artificial Chromosome) clone ends along the chromosome, based on the STS content of each clone, for constructing a composite map that represents the linear order and position of mapping landmarks along the genome.
STS wt Allele definition: Human STS wild-type allele is located in the vicinity of Xp22.32 and is approximately 135 kb in length. This allele, which encodes steryl-sulfatase protein, plays a role in conversion of sulfated steroids to estrogens during pregnancy. Mutations in this gene are associated with steroid sulfatase deficiency.
 
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