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Micrococcal Nuclease definition: An enzyme that catalyzes the endonucleolytic cleavage to 3'-phosphomononucleotide and 3'-phospholigonucleotide end-products. It can cause hydrolysis of double- or single-stranded DNA or RNA. (From Enzyme Nomenclature, 1992) EC 3.1.31.1.
Pneumonia, Staphylococcal definition: Pneumonia caused by infections with bacteria of the genus STAPHYLOCOCCUS, usually with STAPHYLOCOCCUS AUREUS.
Staphylococcal Food Poisoning definition: Poisoning by staphylococcal toxins present in contaminated food.
Staphylococcal Infections definition: Infections with bacteria of the genus STAPHYLOCOCCUS.
Staphylococcus infection definition: infections with bacteria of the genus Staphylococcus; includes staphylococcal pneumonia, staph skin infections, furunculosis, carbuncle, impetigo, Ritter disease, scalded skin syndrome, etc.
Staphylococcus Phages definition: Viruses whose host is Staphylococcus.
Staphylococcal Protein A definition: A protein present in the cell wall of most Staphylococcus aureus strains. The protein selectively binds to the Fc region of human normal and myeloma-derived IMMUNOGLOBULIN G. It elicits antibody activity and may cause hypersensitivity reactions due to histamine release; has also been used as cell surface antigen marker and in the clinical assessment of B lymphocyte function.
staphylococcus aureus protein A definition: A protein that resides in the microbial wall of staphylococcus aureus and interferes with opsonization by binding to the Fc portion of immunoglobulin. The protein has a deleterious effect on the epithelial cells that line the respiratory tract, and plays a role in the induction of pneumonia. Protein A also initiates polymorphonuclear cell migration into airway passages via TNFR1 activation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39057&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39057&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C17166" NCI Thesaurus)
HMGA1a definition: HMGA1a is one of three protein products of the same gene, HMGA1, generated by alternative splicing. The HMGA1a protein contains three basic domains, named AT-hooks and an acidic C-terminal region. AT-hooks are responsible for binding to AT-rich sequences inside the minor groove of DNA. Phosphorylation of HMGA1a by both PKC and cdc-2 kinases strongly reduces its DNA binding affinity and is critical in cell cycle progression. HMGA1a activates the interferon-beta gene (IFN-beta) by functioning as the essential architectural component for the assembly and stability of the IFN-beta enhanceosome. (PMID11576996)
Staphylococcus aureus Protein A definition: A protein that resides in the microbial wall of staphylococcus aureus and interferes with opsonization by binding to the Fc portion of immunoglobulin. The protein has a deleterious effect on the epithelial cells that line the respiratory tract, and plays a role in the induction of pneumonia. Protein A also initiates polymorphonuclear cell migration into airway passages via TNFR1 activation.
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