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Thymic Epithelial Cell definition: A reticular epithelial cell generated in the thymus that affects T-lymphocyte cell production. Thymic epithelial cells are organized in a three-dimensional network rather than as a sheet of cells on a basement membrane.
TEC Protein Tyrosine Kinase definition: Expressed in myeloid, B-, and T-cell lineages by human TEC Gene (TEC Tyr Kinase Family), 631-aa 74-kDa TEC Protein Tyrosine Kinase, a non-receptor protein-tyrosine kinase a containing a PH domain, an SH2 domain, and an SH3 domain, is an integral component of T cell signaling in T cell activation and regulation of immune functions. Human TEC is 60% homologous to mouse Tsk/ltk and 57% homologous to human BTK. Beyond the SH3, SH2, and kinase domains, the TEC family homology involves an N-terminal family-specific domain. TEC is associated with myelodysplastic syndrome. (NCI)
TEC Gene definition: This gene is involved in signal transduction and regulation of immune function.
TEC wt Allele definition: Human TEC wild-type allele is located within 4p12 and is approximately 134 kb in length. This allele, which encodes tyrosine-protein kinase Tec protein, plays a role in both T-cell activation and T-cell signaling.
Nuclear Receptor Subfamily 4, Group A, Member 3 definition: An orphan nuclear receptor that is closely related to members of the thyroid-steroid receptor family. It was originally identified in NERVE CELLS, however it may play regulatory roles in a variety of other tissues.
tec’h definition: Fuite.
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