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TP40 Immunotoxin definition: A chimeric fusion protein containing human transforming growth factor alpha (TGF-a) covalently linked to a truncated form of the bacterial toxin Pseudomonas exotoxin A, PE40, with potential antitumor activity. PE40 lacks the cell-binding domain, but retains domains II and III that are involved in membrane translocation and inhibition of protein synthesis in eukaryotic cells. TGF-a moiety of the TP40 immunotoxin binds to and activates epidermal growth factor receptor (EGFR), a tyrosine kinase receptor overexpressed on certain cancer cells. After internalization, the endotoxin moiety of the immunotoxin-receptor complex causes protein synthesis inhibition via modifying translation elongation factor 2 (EF-2), thereby impedes tumor cell growth and proliferation.
CD7 Gene definition: This gene plays a role in T-cell interactions and is a clinical marker for T-cell acute lymphocytic leukemia.
CD7 wt Allele definition: Human CD7 wild-type allele is located within 17q25.2-q25.3 and is approximately 3 kb in length. This allele, which encodes T-cell antigen CD7 protein, plays an essential role in both T-cell interactions and T-cell/B-cell interactions during early lymphoid development. CD7 gene is the most reliable clinical marker of T-cell acute lymphocytic leukemia.
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