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Genes, p53 definition: Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
TP53 Gene definition: This gene plays a critical role in cell cycle regulation and has tumor suppressor activity.
Tumor Protein p53 definition: A homo-tetrameric, DNA-binding, trans-activator of genes involved in cell division. p53 induces growth arrest or apoptosis and is mutated or inactivated in about 60% of cancers. JNK-p53 and mdm2-p53 complexes regulate ubiquitination and degradation of p53. (from SWISS-PROT P04637, OMIM 191170, and NCI)
Tumor Suppressor Protein p53 definition: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Li-Fraumeni Syndrome definition: Rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites. MUTATION of the p53 tumor suppressor gene, a component of the DNA DAMAGE response pathway, apparently predisposes family members who inherit it to develop certain cancers. The spectrum of cancers in the syndrome was shown to include, in addition to BREAST CANCER and soft tissue sarcomas (SARCOMA); BRAIN TUMORS; OSTEOSARCOMA; LEUKEMIA; and ADRENOCORTICAL CARCINOMA.
Li-Fraumeni syndrome definition: A rare, inherited predisposition to multiple cancers, caused by an alteration in the p53 tumor suppressor gene.
Li Fraumeni syndrome definition: rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites; a point mutation of the p53 tumor suppressor gene apparently predisposes family members who inherit it to develop certain cancers including early breast carcinoma; associated with soft tissue sarcomas and other tumors.
Li-Fraumeni Syndrome definition: An autosomal dominant hereditary neoplastic syndrome caused by an alteration in the p53 tumor suppressor gene. It is characterized by the development of malignant neoplasms at various anatomic sites. The malignant neoplasms associated with Li-Fraumeni syndrome include adrenal cortex carcinoma, astrocytic tumors, colorectal carcinoma, gastric carcinoma, malignant breast neoplasms, medulloblastoma, osteosarcoma, and soft tissue sarcomas.
BCPR Gene definition: This gene is involved in tumor suppression.
BCPR Protein definition: Encoded by human BCPR Gene, BCPR Protein appears to be associated with expression of p53, perhaps regulating its expression. Lesions of BCPR seem to be involved in most breast cancers. (from OMIM and NCI)
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