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Tumor Protein p53 Binding Protein 2 definition: Found only in the cytosol, TP53BP2 impedes cell cycle progression beyond G2/M. It enhances p53 trans-activation function and induces p21 (CDKN1A) expression. TP53BP2 contains ankyrin repeats and an SH3 domain, required for interaction with p53 and BCL2; TP53BP2 cannot bind both proteins simultaneously. (from OMIM 602143 and NCI)
TP53BP2 Gene definition: This gene plays an inhibitory role in G2/M cell cycle progression and stimulates the transactivation of pro-apoptotic genes.
TP53BP2 wt Allele definition: Human TP53BP2 wild-type allele is located in the vicinity of 1q42.1 and is approximately 66 kb in length. This allele, which encodes apoptosis-stimulating of p53 protein 2, plays a role in the regulation of both apoptosis and cellular growth.
 
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