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TP73 Gene definition: This gene is involved in the apoptotic pathway and can have anti or pro apoptotic effects.
TP73 Protein definition: Product of the TP73 gene. A p53 homologue. It is independently activated from p53 and represents a separate route to apoptosis.
TP73 Protein definition: The TP73 protein is the product of a tumor suppressor gene that encodes a protein with sequence similarity to p53; the p53 residues implicated in DNA binding are conserved in p73, which appears to activate some p53-responsive genes and to induce apoptosis. p73 and c-ABL may participate in a mismatch repair-dependent pro-apoptotic signaling pathway. p73 and c-ABL associate through interaction of a c-ABL SH3 domain with a p73 PXXP motif in the C-terminal homooligomerization domain. p73 is a c-ABL kinase substrate; p73 phosphorylation is enhanced by gamma-irradiation. c-ABL stimulates p73-mediated transactivation and apoptosis. T-cells undergoing TCR-AICD, which occurs at a late G1 cell-cycle checkpoint, is dependent on E2F1 and TP73. Expression of E2F1 causes accumulation of p73. (from OMIM 601990 and NCI)
TP73 wt Allele definition: Human TP73 wild-type allele is located in the vicinity of 1p36.33 and is approximately 1 kb in length. This allele, which encodes tumor protein p73, plays a role in the cell cycle and is frequently deleted in neuroblastoma and other cancers.
 
Publications
 

Regulation of p73 by Hck through kinase-dependent and independent mechanisms

Preeti Paliwal et al.

BMC Molecular Biology , 30 May 2007

Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors

Lakshmanane Boominathan

Molecular Cancer , 03 Apr 2007

Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis

Melda Tozluoğlu et al.

Nucleic Acids Research , 01 Sep 2008

P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity

Lili Zhang et al.

Molecular Cancer , 06 Dec 2006

DNA damage induces transcriptional activation of p73 by removing C-EBPα repression on E2F1

Mirko Marabese et al.

Nucleic Acids Research , 15 Nov 2003

p53 and p73 display common and distinct requirements for sequence specific binding to DNA

Maria Lokshin et al.

Nucleic Acids Research , 01 Jan 2007

p73 competes with p53 and attenuates its response in a human ovarian cancer cell line

Faina Vikhanskaya et al.

Nucleic Acids Research , 15 Jan 2000

p53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data

Elisabetta Sbisà et al.

BMC Bioinformatics , 08 Mar 2007

Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML

Eun-Joo Kim et al.

Nucleic Acids Research , 15 Sep 2003

ZEB1 Links p63 and p73 in a Novel Neuronal Survival Pathway Rapidly Induced in Response to Cortical Ischemia

Thai Bui et al.

PLoS ONE , 04 Feb 2009

20 further publications >>