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Antigens, CD28 definition: T-cell differentiation antigens that serve as the receptors for the B7 antigen (ANTIGENS, CD80) which modulates T-cell lymphokine production.
CD28 molecule definition: T lymphocyte surface molecule; involved in T cell activation and IL2 production.
T-Cell Specific Surface Glycoprotein CD28 definition: CD28 encodes a highly glycosylated membrane protein with homology to the Ig superfamily. It also shares significant sequence identity with CTLA-4. Both bind the same ligands, however CTLA-4 binds to B7 with a greater affinity. B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4. CD28 is found on the membrane of resting T-cells. CD28 undergoes tyrosine phosphorylation after interacting with its ligand, B7. Phosphorylation in the cytoplasmic domain of CD28 allows the recruitment of signaling proteins such as PI3K, GRB2, and GADS via their SH2 domains. (OMIM and NCI)
T-Cell Specific Surface Glycoprotein CD28 definition: T-Cell specific surface glycoprotein CD28 (220 aa, 25 kD) is a cell fate protein that is encoded by the human CD28 gene and has roles in regulation of apoptosis and humoral immune response.
CD28 Gene definition: This gene plays several roles in cellular functions specific to the T-cell.
CD28 wt Allele definition: Human CD28 wild-type allele is located within 2q33 and is approximately 31 kb in length. This allele, which encodes T-cell-specific surface glycoprotein CD28 protein, is involved in the costimulation that is essential for CD4 -positive T-cell proliferation, survival, interleukin-2 production, and T-helper type-2 (Th2) development.
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