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X-Ray Repair Cross Complementing Protein 3 definition: X-Ray Repair Cross Complementing Protein 3 (XRCC3), encoded by the XRCC3 gene, is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 interacts directly with RAD51 and may cooperate with RAD51 during recombinational repair. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity and exposure to UV radiation is a major risk factor for the development of malignant melanoma. DNA damage caused by UV radiation is thought to play a major role in carcinogenesis. The association between polymorphisms in DNA repair genes and the development of malignant melanoma, a T allele at position 18067 in exon 7 of the XRCC3 gene is significantly associated with melanoma development. (from OMIM 600675, LocusLink 7517 and NCI)
XRCC3 Gene definition: This gene plays a role in recombination and in the maintenance of DNA integrity.
XRCC3 wt Allele definition: Human XRCC3 wild-type allele is located in the vicinity of 14q32.3 and is approximately 18 kb in length. This allele, which encodes DNA-repair protein XRCC2, plays a role in homologous recombination to maintain chromosomal stability and DNA damage repair.
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