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Yttrium Y 90-Edotreotide definition: A radioconjugate consisting of the octreotide derivative edotreotide labeled with yttrium 90 (Y-90) with potential radiotherapeutic uses. Similar to octreotide, yttrium Y 90-edotreotide binds to somatostatin receptors (SSTRs), especially type 2 receptors, present on the cell membranes of many types of neuroendocrine tumor cells, delivering tissue-specific, beta-emitting nuclide Y-90-mediated cytotoxicity to SSTR-positive cells. Yttrium Y 90-edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide and chelating the substituted octreotide to Y-90 via dodecanetetraacetic acid (DOTA).
yttrium Y 90-DOTA-tyr3-octreotide definition: A radiotherapeutic agent consisting of an analogue of the octapeptide octreotide (SMT 487) chelated to the radioisotope yttrium-90. Yttrium Y 90-DOTA-tyr3-octreotide binds to somatostatin receptor-expressing tumor cells, selectively delivering a cytotoxic dose of beta radiation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38102&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38102&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2601" NCI Thesaurus)
 
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