dict.md logo
Choose languages of interest
SELECT >>
English
German
French
Advertisement:
Definition
 
enEnglish
Judicial Role definition: The kind of action or activity proper to the judiciary, particularly its responsibility for decision making.
Medication Actions definition: Activities related to monitor the use of medicinal substances.
medication administration definition: Activities that involve applying or giving medications and that are completed by clients, parents/caregivers, or health care practitioners.
Medication Treatment definition: Actions performed to administer drugs or remedies regardless of route.
Pharmacologic Management definition: A health/illness/pain management principle specifically directed at the management of pharmacologic agents in maximizing beneficial outcomes and minimizing unfavorable effects.
Behavior Care definition: Actions performed to support observable responses to internal and external stimuli.
Chemical Actions and Uses definition: A group of pharmacologic activities, effects on living systems and the environment, and modes of employment of drugs and chemicals. They are broken into actions, which describe their effects, and uses, which describe how they are employed.
Pharmacologic Actions definition: A broad category of chemical actions and uses that result in the prevention, treatment, cure or diagnosis of disease. Included here are drugs and chemicals that act by altering normal body functions, such as the REPRODUCTIVE CONTROL AGENTS and ANESTHETICS. Effects of chemicals on the environment are also included.
Toxic Actions definition: A broad category of chemical actions with harmful or deadly effect on living organisms.
Nitric Oxide Pathway definition: Nitric oxide (NO) has a number of important physiological actions in the cardiovascular system. In the heart, NO plays a role in keeping the vessels open via vasodilation and prevention of platelet aggregation. It also plays an important role in regulating the force and rate of contraction. In vivo NO is released by shear stress of ligands that increase intracellular Ca2+ in endothelial cells. The increased intracellular Ca2+ activates nitric oxide synthase III (NOSIII) by promoting the binding of Ca/Calmodulin to the enzyme. NOSIII, which is resident in the Golgi complex, is transported together with caveolin-1 to the caveolae at the plasma membrane via vesicles. Shear stress signals via a potassium channel and the cytoskeleton, which results in tyrosine phosphorylation of specific proteins, activation of phosphatidylinositol 3-kinase, and subsequently in activation of Akt kinase. Akt activation by shear stress, but also by VEGF, activates NOSIII by serine phosphorylation, which increases the affinity of NOSIII for calmodulin. After agonist binding at the plasma membrane, NOSIII-activating receptors translocate to caveolae. VEGF receptor signals via its tyrosine kinase domain. Furthermore, agonist receptors activate calcium channels of the endoplasmic reticulum (ER) via phospholipase C and inositol 1,4,5-trisphosphate. This calcium flux induces binding of calmodulin to NOSIII, whereas the NOSIII-caveolin-1 interaction is disrupted. At the same time, NOSIII is translocated into the cytosol. On binding of calmodulin, NOSIII generates NO, is enhanced by the interaction with Hsp90. Once activated, NOSIII catabolizes L-arginine to NO, which diffuses out of the cell. NO stimulates guanylate (G-) cyclase and increases cGMP levels. cGMP activates cGMP-dependent protein kinase (PKG), cGMP-inhibited phosphodiesterase (PDEIII), and cGMP-stimulated phosphodiesterase (PDEII). PKG may reduce the force and rate of contraction, possibly by phosphorylating troponin I or by phosphorylating phospholamban. PDEIII is inhibited by the increases in cGMP brought about by NO. This may result in an increase in cAMP and cAMP-dependent protein kinase (PKA). PKA in turn activates Ca2+ channels, countering the effects of PKG. In contrast, cGMP may stimulate PDEII, reduce cAMP levels and PKA activity, and thereby reduce Ca2+ channel activity. (BioCarta)
1 further definition >>
Publications
 

Anti-inflammatory actions of acupuncture.

Freek J Zijlstra et al.

Mediators of Inflammation , 01 Apr 2003

Properties and actions of bridged diphenyl acaricides.

R B March

Environmental Health Perspectives , 01 Apr 1976

Selected biochemical actions of ovarian hormones.

K S Korach

Environmental Health Perspectives , 01 Apr 1981

Dissociating What and When of Intentional Actions

Veronika Krieghoff et al.

Frontiers in Human Neuroscience , 26 Feb 2009

Attenuation of both apoptotic and necrotic actions of cadmium by Bcl-2.

Masami Ishido et al.

Environmental Health Perspectives , 01 Jan 2002

DNA binding and helicase actions of mouse MCM4/6/7 helicase

Zhiying You et al.

Nucleic Acids Research , 2005

Protective Actions of PPAR- γ Activation in Renal Endothelium

Peter E. Westerweel et al.

PPAR Research , 2008

Cardiovascular actions of palladium compounds in the unanesthetized rat.

M J Wiester

Environmental Health Perspectives , 01 Dec 1975

Cardiovascular actions of lead and relationship to hypertension: a review.

S J Kopp et al.

Environmental Health Perspectives , 01 Jun 1988

Mechanomyographic amplitude and frequency responses during dynamic muscle actions: a comprehensive review

Travis W Beck et al.

BioMedical Engineering OnLine , 19 Dec 2005

776 further publications >>