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Translation
 
enEnglish caCatalan
1 word
aflatoxin aflatoxina
 
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enEnglish deGerman
1 word
aflatoxin Aflatoxin
 
enEnglish esSpanish
1 word
aflatoxin aflatoxina
 
enEnglish frFrench
1 word
aflatoxin aflatoxine
 
enEnglish plPolish
1 word
aflatoxin aflatoksyna
 
enEnglish skSlovak
1 word
aflatoxin aflatoxín
 
deGerman enEnglish
1 word
Aflatoxin aflatoxin
 
deGerman caCatalan
1 word
Aflatoxin aflatoxina
 
deGerman esSpanish
1 word
Aflatoxin aflatoxina
 
deGerman frFrench
1 word
Aflatoxin aflatoxine
 
deGerman plPolish
1 word
Aflatoxin aflatoksyna
 
deGerman skSlovak
1 word
Aflatoxin aflatoxín
 
skSlovak enEnglish
1 word
aflatoxín aflatoxin
 
skSlovak caCatalan
1 word
aflatoxín aflatoxina
 
skSlovak deGerman
1 word
aflatoxín Aflatoxin
 
skSlovak esSpanish
1 word
aflatoxín aflatoxina
 
skSlovak frFrench
1 word
aflatoxín aflatoxine
 
skSlovak plPolish
1 word
aflatoxín aflatoksyna
 
Definition
 
enEnglish
Aflatoxins definition: Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.
aflatoxin definition: a group of closely related toxic metabolites that are designated mycotoxins; produced by Aspergillus flavus and Aspergillus parasiticus.
aflatoxins definition: (AF-la-TOK-sins) Harmful substances made by certain types of mold (Aspergillus flavus and Aspergillus parasiticus) that are often found on poorly stored grains and nuts. Consumption of foods contaminated with aflatoxins is a risk factor for primary liver cancer.
Aflatoxin definition: A group of closely related toxic metabolites that are designated mycotoxins. They are produced by Aspergillus flavus and A. parasiticus. Members of the group include aflatoxin B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; aflatoxin M1; and aflatoxin M2. (MeSH)
Aflatoxin B1 definition: A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
Aflatoxin M1 definition: A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
Aldo-Keto Reductase 7 definition: Encoded by human oncogene AKR7A2 Gene, widely expressed 330-amino acid 36.6 kD AFAR polypeptide (Aldo/Keto Reductase 2 Family) is similar to rat Afar, to a Shaker-related voltage-gated potassium channel, and to aldose reductase. Aldoketoreductases (AKRs) detoxify aldehydes and ketones; AFAR is the principal liver reductase for 2-carboxybenzaldehyde and can metabolize Aflatoxin B1 protein-binding dihydrodiol. AFAR may protect the liver against the toxic and carcinogenic effects of Aflatoxin B1. (OMIM, Swiss-Prot, and NCI)
aflatoxin metabolic process definition: The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. [GOC:ai]
aflatoxin biosynthetic process definition: The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. [ISBN:0716731363, ISBN:0815316194]
aflatoxin catabolic process definition: The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. [GOC:ai]
5 further definitions >>
deGerman
Aflatoxin definition: [1] Biochemie: mutagenes und krebserregendes Gift (Toxin), das von einigen Schimmelpilzarten gebildet wird
 
Publications
 

Dip-strip method for monitoring environmental contamination of aflatoxin in food and feed: use of a portable aflatoxin detection kit.

R B Sashidhar

Environmental Health Perspectives , 01 Oct 1993

Modification of immune function through exposure to dietary aflatoxin in Gambian children.

Paul C Turner et al.

Environmental Health Perspectives , 01 Feb 2003

Does aflatoxin exposure in the United Kingdom constitute a cancer risk?

J C Harrison et al.

Environmental Health Perspectives , 01 Mar 1993

Workgroup Report: Public Health Strategies for Reducing Aflatoxin Exposure in Developing Countries

Heather Strosnider et al.

Environmental Health Perspectives , 01 Dec 2006

Aflatoxin-Related Immune Dysfunction in Health and in Human Immunodeficiency Virus Disease

Yi Jiang et al.

Clinical and Developmental Immunology , 2008

Aflatoxin Exposure and Viral Hepatitis in the Etiology of Liver Cirrhosis in The Gambia, West Africa

Mark H. Kuniholm et al.

Environmental Health Perspectives , 01 Nov 2008

Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus.

C P Wild et al.

Environmental Health Perspectives , 01 Mar 1993

Phylogenetic analysis of homologous fatty acid synthase and polyketide synthase involved in aflatoxin biosynthesis

Marina Marcet-Houben et al.

Bioinformation , 20 Sep 2008

Aflatoxin Contamination of Commercial Maize Products during an Outbreak of Acute Aflatoxicosis in Eastern and Central Kenya

Lauren Lewis et al.

Environmental Health Perspectives , 01 Dec 2005

Exposure to aflatoxin B1 in animal-feed production plant workers.

J L Autrup et al.

Environmental Health Perspectives , 01 Mar 1993

54 further publications >>