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Translation
 
enEnglish deGerman
1 word
agonist Agonist
agonist Muskel, der eine entgegengesetzte Bewegung ausführt
 
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deGerman enEnglish
1 word
Agonist agonist
 
Definition
 
enEnglish
Adrenergic alpha-Agonists definition: Drugs that selectively bind to and activate alpha adrenergic receptors.
Alpha-Adrenergic Agonist definition: Natural or synthetic Alpha-adrenergic Agonists selectively bind to and activate alpha adrenergic receptors of the sympathetic nervous system, mimicking the actions of natural sympathomimetic neurotransmitters (norepinephrine and related substances). Alpha-adrenergic Agonists can initiate physiological responses such as vasoconstriction, pupil dilation, and contraction of pilomotor muscles. (NCI04)
Adrenergic beta-Agonists definition: Drugs that selectively bind to and activate beta-adrenergic receptors.
Adrenergic Agonists definition: Drugs that bind to and activate adrenergic receptors.
Calcium Channel Agonists definition: Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.
Deslorelin definition: A synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04)
deslorelin definition: A synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=357620&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=357620&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38709" NCI Thesaurus)
Serotonin Agonists definition: Agents that have an affinity for serotonin receptors and are able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. These compounds are used as antidepressants, anxiolytics, and in the treatment of MIGRAINE DISORDERS.
Histamine Agonists definition: Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically.
Dopamine Agonists definition: Drugs that bind to and activate dopamine receptors.
14 further definitions >>
slSlovenian
agonist definition: agoniste.
agonist definition: ''Nominatif singulier du nom'' agonist.
agonist definition: ''Accusatif singulier du nom'' agonist.
 
Examples
 

Muscarinic acetylcholine receptors (mAChRs) undergo agonist-promoted internalization, but evidence suggesting that the mechanism of internalization is β-arrestin dependent has been contradictory and unclear.

Kymry T Jones et al.

Journal of Molecular Signaling 1 (7), 05 12월 2006

Previous studies using heterologous over-expression of wild type or dominant-negative forms of β-arrestins have reported that agonist-promoted internalization of M 2 mAChRs is a β-arrestin- and clathrin-independent phenomenon.

Kymry T Jones et al.

Journal of Molecular Signaling 1 (7), 05 12월 2006

In order to circumvent the complications associated with the presence of endogenous β-arrestin that may have existed in these earlier studies, we examined agonist-promoted internalization of the M 2 mAChR in mouse embryonic fibroblasts (MEFs) derived from β-arrestin knockout mice that lack expression of either one or both isoforms of β-arrestin (β-arrestin 1 and 2).

Kymry T Jones et al.

Journal of Molecular Signaling 1 (7), 05 12월 2006

In wild type MEF cells transiently expressing M 2 mAChRs, 40% of surface M 2 mAChRs underwent internalization and sorted into intracellular compartments following agonist stimulation.

Kymry T Jones et al.

Journal of Molecular Signaling 1 (7), 05 12월 2006

In contrast, M 2 mAChRs failed to undergo internalization and sorting into intracellular compartments in MEF β-arrestin double knockout cells following agonist stimulation.

Kymry T Jones et al.

Journal of Molecular Signaling 1 (7), 05 12월 2006

488 further examples >>
Publications
 

Agonist mediated internalization of M 2 mAChR is β-arrestin-dependent

Kymry T Jones et al.

Journal of Molecular Signaling , 05 Dec 2006

Pharmacological challenge with a serotonin 1D agonist in alcohol dependence

Bavanisha Vythilingum et al.

BMC Psychiatry , 24 Aug 2005

Effects of the noradrenergic agonist clonidine on temporal and spatial attention

Sander Nieuwenhuis et al.

Psychopharmacologia , 01 Aug 2007

Extrinsic factors regulate partial agonist efficacy of strychnine-sensitive glycine receptors

Jeffrey S Farroni et al.

BMC Pharmacology , 09 Aug 2004

Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity

Zhengyu Ma et al.

PLoS Biology , 01 Feb 2008

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3

Naohide Watanabe et al.

The Journal of Cell Biology , 30 Jun 2008

The NMDA Agonist D-Cycloserine Facilitates Fear Memory Consolidation in Humans

Raffael Kalisch et al.

Cerebral Cortex (New York, NY) , 01 Jan 2009

Dopamine Agonist Increases Risk Taking but Blunts Reward-Related Brain Activity

Jordi Riba et al.

PLoS ONE , 25 Jun 2008

Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells

D Pugazhendhi et al.

The Journal of Endocrinology , 01 Jun 2008

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2 * S⃞

Jun Mori et al.

The Journal of Biological Chemistry , 19 Dec 2008

483 further publications >>