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1 word
agonists Agonisten
 
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Definition
 
enEnglish
Adrenergic alpha-Agonists definition: Drugs that selectively bind to and activate alpha adrenergic receptors.
Alpha-Adrenergic Agonist definition: Natural or synthetic Alpha-adrenergic Agonists selectively bind to and activate alpha adrenergic receptors of the sympathetic nervous system, mimicking the actions of natural sympathomimetic neurotransmitters (norepinephrine and related substances). Alpha-adrenergic Agonists can initiate physiological responses such as vasoconstriction, pupil dilation, and contraction of pilomotor muscles. (NCI04)
Adrenergic beta-Agonists definition: Drugs that selectively bind to and activate beta-adrenergic receptors.
Adrenergic Agonists definition: Drugs that bind to and activate adrenergic receptors.
Calcium Channel Agonists definition: Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.
Vasoconstrictor Agents definition: Drugs used to cause constriction of the blood vessels.
Serotonin Agonists definition: Agents that have an affinity for serotonin receptors and are able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. These compounds are used as antidepressants, anxiolytics, and in the treatment of MIGRAINE DISORDERS.
Histamine Agonists definition: Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically.
Dopamine Agonists definition: Drugs that bind to and activate dopamine receptors.
dopamine agonist definition: class of drugs and natural products which enhance dopaminergic function by increasing dopamine biosynthesis, decreasing dopamine degradation or reuptake, or interacting positively with dopamine receptors.
10 further definitions >>
Examples
 

Principally as a result of the difficulty in identifying potent and selective agonists, the A 2B AR is the least extensively characterised of the adenosine receptors family.

Pier Giovanni Baraldi et al.

Purinergic Signalling 4 (4), 01 Dec 2008

As A 2B AR signalling seems to be associated with pre/postconditioning cardioprotective and anti-inflammatory mechanisms, selective agonists may represent a new therapeutic group for patients suffering from coronary artery disease.

Pier Giovanni Baraldi et al.

Purinergic Signalling 4 (4), 01 Dec 2008

Herein we present an overview of the recent advancements in identifying potent and selective A 2B AR agonists reported in scientific and patent literature.

Pier Giovanni Baraldi et al.

Purinergic Signalling 4 (4), 01 Dec 2008

Nucleoside-based agonists are the result of modifying adenosine by substitution at the N 6 -, C 2 -positions of the purine heterocycle and/or at the 5′-position of the ribose moiety or combinations of these substitutions.

Pier Giovanni Baraldi et al.

Purinergic Signalling 4 (4), 01 Dec 2008

Compounds 1-deoxy-1-{6-[ N ′-(furan-2-carbonyl)-hydrazino]-9 H -purin-9-yl}-N-ethyl- β -D-ribofuranuronamide ( 19 , hA 1 K i  = 1050 nM, hA 2A K i  = 1550 nM, hA 2B EC 50  = 82 nM, hA 3 K i  > 5 μM) and its 2-chloro analogue 23 (hA 1 K i  = 3500 nM, hA 2A K i  = 4950 nM, hA 2B EC 50  = 210 nM, hA 3 K i  > 5 μM) were confirmed to be potent and selective full agonists in a cyclic adenosine monophosphate (cAMP) functional assay in Chinese hamster ovary (CHO) cells expressing hA 2B AR.

Pier Giovanni Baraldi et al.

Purinergic Signalling 4 (4), 01 Dec 2008

390 further examples >>
Publications
 

PPAR Agonists and Cardiovascular Disease in Diabetes

Anna C. Calkin et al.

PPAR Research , 2008

Recent improvements in the development of A 2B adenosine receptor agonists

Pier Giovanni Baraldi et al.

Purinergic Signalling , 01 Dec 2008

Octopaminergic agonists for the cockroach neuronal octopamine receptor

Akinori Hirashima et al.

Journal of Insect Science , 21 Apr 2003

PPAR γ Agonists: Potential as Therapeutics for Neovascular Retinopathies

Harrihar A. Pershadsingh et al.

PPAR Research , 2008

Should We Use PPAR Agonists to Reduce Cardiovascular Risk?

Jennifer G. Robinson

PPAR Research , 2008

Anti-Inflammatory Preconditioning by Agonists of Adenosine A1 Receptor

Sigal Nakav et al.

PLoS ONE , 07 May 2008

Regulation of Glial Cell Functions by PPAR- γ Natural and Synthetic Agonists

Antonietta Bernardo et al.

PPAR Research , 2008

Comparison of human B cell activation by TLR7 and TLR9 agonists

John A Hanten et al.

BMC Immunology , 24 Jul 2008

Rat Urinary Bladder Carcinogenesis by Dual-Acting PPAR α + γ Agonists

Martin B. Oleksiewicz et al.

PPAR Research , 2008

Bench-to-bedside review: β 2 -Agonists and the acute respiratory distress syndrome

Gavin D Perkins et al.

Critical Care , 2004

385 further publications >>