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arginine catabolic process definition: The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. [ChEBI:29016, GOC:go_curators]
arginine catabolic process to glutamate definition: The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate. [GOC:go_curators]
arginine catabolic process to ornithine definition: The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine. [GOC:go_curators]
arginine catabolic process to proline definition: The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline. [GOC:go_curators]
arginine catabolic process to spermine definition: The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine. [GOC:go_curators]
arginine catabolic process to succinate definition: The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate. [GOC:go_curators]
arginine catabolic process to alanine via ornithine definition: The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine. [GOC:pz]
arginine catabolic process to proline via ornithine definition: The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine. [GOC:pz]
 
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Publications
 

Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803

Sarah Schriek et al.

BMC Genomics , 28 Nov 2007

Ornithine-δ-aminotransferase is essential for Arginine Catabolism but not for Proline Biosynthesis

Dietmar Funck et al.

BMC Plant Biology , 17 Apr 2008

In vitro analysis of the interaction between the small RNA SR1 and its primary target ahrC mRNA: ... in regulation of arginine catabolism by basepairing with its ...

Nadja Heidrich et al.

Nucleic Acids Research , 01 Jul 2007

Age-Related Alteration of Arginase Activity Impacts on Severity of Leishmaniasis: ... arginase-mediated L-arginine metabolism differs with age. Methodology The age distribution of patients with visceral or cutaneous leishmaniasis was determined in cohorts of patients in our clinics in endemic areas in Ethiopia. To exclude factors that are difficult to control in patients, we assessed the impact of ageing on the manifestations of experimental leishmaniasis. We determined parasite burden, T cell responses, and macrophage effector functions in young and aged mice during the course of infection. Results Our results show that younger mice develop exacerbated lesion pathology and higher parasite burdens than aged mice. This aggravated disease development in younger individuals does not correlate with a change in T helper cytokine profile. To address the underlying mechanisms responsible for the more severe infections in younger mice, we investigated macrophage effector functions. Our results show that macrophages from younger mice do not have an impaired capacity to kill parasites; however, they express significantly higher levels of arginase 1 than aged mice and promote parasite growth more efficiently. Thus, our results demonstrate that ageing differentially impacts on L-arginine metabolism and subsequent effector functions of physiologically distinct macrophage subsets. Conclusions Here, we show that arginase-mediated L-arginine metabolism is modulated with age and affects the capacity of macrophages to express arginase; the increased capacity to upregulate this enzyme in younger individuals results in a more permissive environment for parasite growth, increased disease severity and pathology. These results suggest that the difference in arginase-mediated L-arginine catabolism is likely to be an ...

Ingrid Müller et al.

PLoS Neglected Tropical Diseases , 14 May 2008