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Alprazolam definition: A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)
alprazolam definition: 8-chloro-1-methyl-6-phenyl-s-triazolo benzodiazepine, has both antidepressant and anxiolytic properties; possible efficacy in alcohol withdrawal therapy; abuse can lead to habituation or addiction.
alprazolam definition: A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39659&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39659&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C227" NCI Thesaurus)
Alprazolam definition: A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability.
Benzodiazepines definition: A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.
benzodiazepine definition: bicyclic structure consisting of fused benzene and diazepine rings; many compounds with this structure have psychotropic and neurotropic properties, and are used as sedatives, anticonvulsants, muscle relaxants, and in related applications.
Benzodiazepine definition: Drugs from this chemical class are used for their central nervous system depressant properties including sedation, facilitation of sleep, seizure control, general anesthesia, anxiolytic, amnestic, and for detoxification from similar (cross tolerant) drugs
Estazolam definition: A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than DIAZEPAM or NITRAZEPAM.
Estazolam definition: A triazolo-benzodiazepine with anxiolytic, anticonvulsant, hypnotic, and muscle relaxant properties. Estazolam binds to the gamma-aminobutyric acid (GABA) receptor at a site distinct from the inhibitory neurotransmitter GABA binding site in the limbic system of the central nervous system (CNS). This binding leads to an opening of the chloride channels, which allows the flow of chloride ions into the neuron, hyperpolarizes the neuronal membrane, inhibits neuronal firing, and leads to a decrease in neuronal excitability.
Midazolam definition: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
14 further definitions >>
Examples
 

The objective of this study is to assess if some of the risk factors for falls are associated with new benzodiazepine prescriptions in elderly persons.

Gillian Bartlett et al.

BMC Family Practice 10 (7), 06 Jan 2009

Using provincial administrative databases, elderly Quebec residents were screened in 1989 for benzodiazepine use and non-users were followed for up to 5 years.

Gillian Bartlett et al.

BMC Family Practice 10 (7), 06 Jan 2009

Logistic regression models were used to evaluate potential predictors of new benzodiazepine use among patient baseline characteristics.

Gillian Bartlett et al.

BMC Family Practice 10 (7), 06 Jan 2009

In the 252,811 elderly patients who had no benzodiazepine prescription during the baseline year (1989), 174,444 (69%) never filled a benzodiazepine prescription and 78,367 (31%) filled at least one benzodiazepine prescription.

Gillian Bartlett et al.

BMC Family Practice 10 (7), 06 Jan 2009

In the adjusted analysis, several risk factors for falls were associated with statistically significant increases in the risk of receiving a new benzodiazepine prescription including the number of prescribing physicians seen at baseline (OR: 1.12; 95% CI 1.11–1.13), being female (OR: 1.20; 95% CI 1.18–1.22) or a diagnosis of arthritis (OR: 1.11; 95% CI 1.09–1.14), depression (OR: 1.42; 95% CI 1.35–1.49) or alcohol abuse (OR: 1.24; 95% CI 1.05–1.46).

Gillian Bartlett et al.

BMC Family Practice 10 (7), 06 Jan 2009

31 further examples >>
Publications
 

Association between risk factors for injurious falls and new benzodiazepine prescribing in elderly persons

Gillian Bartlett et al.

BMC Family Practice , 06 Jan 2009

Long term benzodiazepine use for insomnia in patients over the age of 60: discordance of patient and physician perceptions

Leevin Mah et al.

BMC Family Practice , 08 May 2002

Transition Metal Complexes of Quinolino[3,2-b]benzodiazepine and Quinolino[3,2-b]benzoxazepine: Synthesis, Characterization, and Antimicrobial Studies

B. Basavaraju et al.

Bioinorganic Chemistry and Applications , 2007

Benzodiazepine prescribing behaviour and attitudes: a survey among general practitioners practicing in northern Thailand

Manit Srisurapanont et al.

BMC Family Practice , 23 Jun 2005

A quantitative assay to measure the relative DNA-binding affinity of pyrrolo[2,1-c] [1,4]benzodiazepine (PBD) antitumour antibiotics based on the inhibition of restriction endonuclease BamHI.

M S Puvvada et al.

Nucleic Acids Research , 11 Aug 1993

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1- c ][1,4]benzodiazepine dimer SJG-136

Peter H. Clingen et al.

Nucleic Acids Research , 2005

Between benzodiazepine over-sedation and neurological damage

Jordan Kountchev et al.

Critical Care , 2005

Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors

Marjan Nassiri-Asl et al.

BMC Complementary and Alternative Medicine , 08 Aug 2007

Is melatonin helpful in stopping the long-term use of hypnotics? A discontinuation trial: ... discontinuation of benzodiazepine (BD) therapy in ...

Frans H.J.A. Vissers et al.

Pharmacy World & Science , 01 Dec 2007

Response to diazepam in children with malaria induced seizures: ... the binding capacity of benzodiazepine receptors in mice. We ...

M.L. Ikumi et al.

Epilepsy Research , 01 Dec 2008

26 further publications >>