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Bone Morphogenetic Protein 4 definition: A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.
 
Examples
 

01 10 2007 139 2 321 330 17 4 2007 11 7 2007 © 2007 The Authors Journal Compilation © 2007 Blackwell Publishing Ltd 2007 The transforming growth factor- β -related factor bone morphogenetic protein 4 (BMP4) is expressed in the human embryonic aorta-gonad-mesonephros (AGM) coincident with the emergence of haematopoietic cells and influences postnatal mammalian haematopoietic stem cells in vitro .

Caroline J Marshall et al.

British Journal of Haematology 139 (2), 01 Oct 2007

A number of extrinsic factors have been reported to influence haematopoiesis including members of the hedgehog, Wnt, Notch and transforming growth factor- β (TGF β )/bone morphogenetic protein (BMP) families ( Fortunel et al , 2000 ; Bhardwaj et al , 2001 ; Kumano et al , 2003 ; Reya et al , 2003 ; Sadlon et al , 2004 ; Androutsellis-Theotokis et al , 2006 ; Neves et al , 2006 ).

Caroline J Marshall et al.

British Journal of Haematology 139 (2), 01 Oct 2007

During lower vertebrate ( Xenopus ) embryogenesis the genetic programming of putative haemangioblasts is regulated by bone morphogenetic protein 4 (BMP4) ( Walmsley et al , 2002 ).

Caroline J Marshall et al.

British Journal of Haematology 139 (2), 01 Oct 2007

Fig 1 Mid gestation murine CD34 + aorta-gonad-mesonephros (AGM) cells contain subpopulations that differ in levels of c-Kit expression, differentiation potential and response to bone morphogenetic protein 4 (BMP4). (A) AGM cells (10·5 dpc) were analysed by flow cytometry (CyAn ADP Flow Cytometer) for expression of CD34, c-Kit, Flk1 and CD45 to identify subpopulations.

Caroline J Marshall et al.

British Journal of Haematology 139 (2), 01 Oct 2007

Fig 2 Bone morphogenetic protein 4 (BMP4) increases the plating efficiency (growth/survival) of mid-gestation aorta-gonad-mesonephros (AGM)-derived CD34 + /c-Kit high cells in 10-d culture. (A) Addition of BMP4 (open symbols) results in an increase in the number of colonies produced at 10·5 dpc compared with serum-free conditions (−BMP4, solid symbols).

Caroline J Marshall et al.

British Journal of Haematology 139 (2), 01 Oct 2007

2 further examples >>
Publications
 

Role of RGM coreceptors in bone morphogenetic protein signaling

Peter J Halbrooks et al.

Journal of Molecular Signaling , 05 Jul 2007

YY1 activates Msx2 gene independent of bone morphogenetic protein signaling

D. P. Tan et al.

Nucleic Acids Research , 01 Mar 2002

Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease

Melina Daans et al.

Arthritis Research & Therapy , 2008

Lead Induces Chondrogenesis and Alters Transforming Growth Factor-β and Bone Morphogenetic Protein Signaling in Mesenchymal Cell Populations

Michael J. Zuscik et al.

Environmental Health Perspectives , 01 Sep 2007

The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle

Gregory F Erickson et al.

Reproductive biology and endocrinology : RB&E , 05 Feb 2003

Bone morphogenetic protein 4 modulates c-Kit expression and differentiation potential in murine embryonic aorta-gonad-mesonephros haematopoiesis in vitro

Caroline J Marshall et al.

British Journal of Haematology , 01 Oct 2007

Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation: therapeutic implications

Manolis Heliotis et al.

Arthritis Research & Therapy , 2008

A rapid and sensitive bioassay to measure bone morphogenetic protein activity

Lior Zilberberg et al.

BMC Cell Biology , 19 Sep 2007

The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein

Hong Namkoong et al.

BMC Cancer , 18 Mar 2006

Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein 2 (rhBMP-2). A pilot study in dogs

Jürgen Becker et al.

Clinical Oral Investigations , 01 Sep 2006

52 further publications >>