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Bone Morphogenetic Protein 7 definition: A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
Bone Morphogenetic Protein 7 definition: Bone Morphogenetic Protein 7 (BMP7), encoded by the BMP7 gene, is a member of the TGF-beta family. BMP7 signals through receptor serine/threonine kinases and has very strong similarity to murine Bmp7. BMP7 plays a role in calcium regulation and bone homeostasis. It induces cartilage and bone formation and may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. BMP7 is expressed in the kidney and bladder and lower levels are seen in the brain. At all anatomical sites disrupted by Holt-Oram syndrome mutations, BMP7 is expressed in all structures that are altered in Holt-Oram Syndrome patients, including the heart, proximal and distal forelimb, clavicle, and scapula, as well as other unaffected tissues. (NCI)
BMP7 Gene definition: This gene is involved in calcium regulation and bone homeostasis. It also plays a role in the control of cellular development and differentiation.
BMP7 wt Allele definition: Human BMP7 wild-type allele is located within 20q13 and is approximately 96 kb in length. This allele, which encodes bone morphogenetic protein 7, plays a role in embryogenesis and bone induction.
 
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Publications
 

Role of RGM coreceptors in bone morphogenetic protein signaling

Peter J Halbrooks et al.

Journal of Molecular Signaling , 05 Jul 2007

YY1 activates Msx2 gene independent of bone morphogenetic protein signaling

D. P. Tan et al.

Nucleic Acids Research , 01 Mar 2002

Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease

Melina Daans et al.

Arthritis Research & Therapy , 2008

Lead Induces Chondrogenesis and Alters Transforming Growth Factor-β and Bone Morphogenetic Protein Signaling in Mesenchymal Cell Populations

Michael J. Zuscik et al.

Environmental Health Perspectives , 01 Sep 2007

The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle

Gregory F Erickson et al.

Reproductive biology and endocrinology : RB&E , 05 Feb 2003

Bone morphogenetic protein 4 modulates c-Kit expression and differentiation potential in murine embryonic aorta-gonad-mesonephros haematopoiesis in vitro

Caroline J Marshall et al.

British Journal of Haematology , 01 Oct 2007

Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation: therapeutic implications

Manolis Heliotis et al.

Arthritis Research & Therapy , 2008

A rapid and sensitive bioassay to measure bone morphogenetic protein activity

Lior Zilberberg et al.

BMC Cell Biology , 19 Sep 2007

The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein

Hong Namkoong et al.

BMC Cancer , 18 Mar 2006

Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein 2 (rhBMP-2). A pilot study in dogs

Jürgen Becker et al.

Clinical Oral Investigations , 01 Sep 2006

52 further publications >>