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Definition
 
enEnglish
Chromosome Breakage definition: A type of chromosomal aberration involving DNA BREAKS. Chromosome breakage can result in CHROMOSOMAL TRANSLOCATION; CHROMOSOME INVERSION; or SEQUENCE DELETION.
chromosome breakage definition: Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage. [GOC:ns]
Nijmegen breakage syndrome (NBS) definition: A disorder, wherein unstable chromosomes have a tendency to break and become rearranged, characterized by microcephaly, stunted growth, subnormal mental development, cafe-au-lait spots, and immunodeficiency. The syndrome is named after the University of Nijmegen in the Netherlands.
Nijmegen Breakage Syndrome definition: A disorder, wherein unstable chromosomes have a tendency to break and become rearranged, characterized by microcephaly, stunted growth, subnormal mental development, cafe-au-lait spots, and immunodeficiency. The syndrome is named after the University of Nijmegen in the Netherlands. (JABL99)
Nijmegen breakage syndrome definition: characterized by short stature, progressive microcephaly with loss of cognitive skills, premature ovarian failure in females, recurrent sinopulmonary infections, and an increased risk for cancer, particularly lymphoma.
Nijmegen Breakage Syndrome definition: A chromosome instability syndrome resulting from a defective response to DNA double-strand breaks. In addition to characteristic FACIES and MICROCEPHALY, patients have a range of findings including RADIOSENSITIVITY, immunodeficiency, increased cancer risk, and growth retardation. Causative mutations occur in the NBS1 gene, located on human chromosome 8q21. NBS1 codes for nibrin, the key regulator protein of the R/M/N (RAD50/MRE11/NBS1) protein complex which senses and mediates cellular response to DNA DAMAGE caused by IONIZING RADIATION.
Nibrin definition: Encoded by human NBS1 Gene, ubiquitous expression of 754-amino acid 85 kD Nibrin occurs principally in testis, thymus, and spleen (sites of physiologic DNA double-strand breakage) and liver, lung, striated/smooth muscle, kidney, and gut (high proliferative activity). Nibrin contains a forkhead-associated domain and a C-terminal breast cancer domain. As part of the p95/NBS1/p200/p400/MRE11/RAD50 and the BASC complexes, NBS1 participates in DNA repair and meiotic recombination. Serine phosphorylation by ATM is linked to S-phase checkpoint activation. Nibrin/gamma-H2AX associate with V(D)J recombination sites in response to RAG1-mediated cleavage. Ig Class switch DNA recombination recruits NBS1/gamma-H2AX in G1. NBS1 mutations are associated with Nijmegen breakage syndrome, chromosomal instability, cancer, and cell cycle checkpoint defects. (from Swiss-Prot, OMIM, and NCI)
NBN wt Allele definition: Human NBN wild-type allele is located within 8q21 and is approximately 51 kb in length. This allele, which encodes nibrin protein, is involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. Functional mutations in the NBN gene produce allelic variants that are involved in Nijmegen breakage syndrome.
Break definition: Issue associated with undesired damage or breakage of those materials used in device construction.
insurance against breakage definition: [1] Bruchschadenversicherung
1 further definition >>
deGerman
Bruch definition: [1] das körperliche Brechen, Zertrennen eines Gegenstandes; Materials; der Ort des Brechens; ein Auseinandergehen, Trennen im weitesten Sinne von Gegenständen, Materialien, Verbindungen, Zusammenschlüssen [2] Anatomie: eine Knochenfraktur bei Menschen und Tieren [3] Anatomie: ein Eingeweidebruch bei Menschen und Tieren [4] ein Nichteinhalten einer Vereinbarung, Vertrages, Übereinkunft [5] das (gewaltsame) Auflösen, Lösen einer Verbindung [6] synonym für: zerbrochene und damit meist in ihrem Wert geminderte Ware [7] Textiltechnik, Schneidereihandwerk: ein eingebrachter Knick in einer Stoffbahn, in einem Bekleidungsstück [8] Geologie: eine Verwerfung, eine Störungszone [9] kurz für: ein Steinbruch [10] Mathematik: die Darstellung eines Quotienten von Termen, insbesondere von ganzen Zahlen, bei der man einen zumeist horizontalen horizontalen Bruchstrich zieht, über diesem den Dividenden schreibt und unterhalb den Divisor. [11] Jägersprache: abgebrochener Zweig [12] Gangstersprache, gaunersprachlich, Rotwelsch: ein Einbruch, [13] veraltet: lange, weite Hose, die zum Beispiel Schiffer und Bauern trugen [14] Molkereiwesen: geronnene und mit der Käseharfe zerteilte Milch, ein Zwischenprodukt bei der Käseherstellung
 
Publications
 

The mechanism of DNA breakage by phleomycin in vitro.

M J Sleigh

Nucleic Acids Research , 01 Apr 1976

The Fragile Breakage versus Random Breakage Models of Chromosome Evolution

Qian Peng et al.

PLoS Computational Biology , 01 Feb 2006

The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

S E Porter et al.

Nucleic Acids Research , 11 Nov 1989

A long stringent sequence signal for programmed chromosome breakage in Tetrahymena thermophila

Qichang Fan et al.

Nucleic Acids Research , 15 Feb 2000

Mechanistic studies on depurination and apurinic site chain breakage in oligodeoxyribonucleotides.

T Suzuki et al.

Nucleic Acids Research , 25 Nov 1994

Random-breakage mapping method applied to human DNA sequences.

M Löbrich et al.

Nucleic Acids Research , 15 May 1996

Selective breakage of DNA alongside 5-bromodeoxyuridine nucleotide residues by high temperature hydrolysis.

G W Grigg

Nucleic Acids Research , 01 Apr 1977

Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA.

M D Been et al.

Nucleic Acids Research , 11 Apr 1984

Breakage of single-stranded DNA by rat liver nicking-closing enzyme with the formation of a DNA-enzyme complex.

M D Been et al.

Nucleic Acids Research , 20 Dec 1980

Cloning and characterization of chromosome breakpoints of Plasmodium falciparum: breakage and new telomere formation occurs frequently and randomly in subtelomeric genes.

A Scherf et al.

Nucleic Acids Research , 11 Apr 1992

124 further publications >>