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Protein Kinase A C-Gamma definition: Encoded by human PRKACG Gene (cAMP Ser/Thr Protein Kinase Family), 350-aa 40-kDa Protein Kinase A C-Gamma (may be testis-specific) is a catalytic subunit of tetrameric inactive cytoplasmic holoenzyme Protein Kinase A. Homo- or heterodimeric regulatory subunits of inactive PKA holoenzyme are associated with two catalytic subunits. Most cellular effects of cAMP are mediated through PKA. cAMP-induced dissociation of holoenzyme releases a dimer of cAMP-bound regulatory subunits and free monomeric catalytic subunits that serine/threonine phosphorylate many cytoplasmic and nuclear substrates. (NCI)
 
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