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We identified centromere protein F (CENP-F) and CDC6 were upregulated in tumors with high SUVs.

Shigeto Ueda et al.

BMC Cancer 8 (7), 22 Dec 2008

High/Low ratio a) Function 1 CENPF centromere protein F (mitosin) NM016343 3.66 cell-cycle regulation 2 CDC6 cell division cycle 6 NM001254 3.36 cell-cycle regulation 3 gtf2b general transcription factor IIB M76766 2.79 transcription initiation 4 Fgr Gardner-Rasheed feline sarcoma viral oncogene homolog NM005248 2.49 mast cell activation 5 GAPDHS glyceraldehyde-3-phosphate_dehydrogenase NM002046 2.18 carbohydrate metabolism 6 Oaz1 ornithine decarboxylase 1 NM002539 2.14 regulation of polyamine synthesis 7 ACTA1 actin, alpha 2, smooth muscle, aorta NM001613 2.1 cell motility, structure 8 KRT5 keratin 5 NM000424 2.05 type 2 cytokeratine 9 RCC1 chromosome condensation 1 NM001269 2.03 cell-cycle regulation 10 BAK1 BCL2-antagonist/killer 1 NM001188 1.96 anti- or pro-apoptotic regulators 11 MMP9 matrix metalloproteinase 9 NM004994 1.95 embryonic development and tissue remodeling 12 MAP2K5 mitogen-activated protein kinase kinase 5 NM002757 1.94 Kinase related to signal cascade 13 MAP2K2 mitogen-activated protein kinase kinase 2 NM030662 1.93 Kinase related to signal cascade 14 Litaf LPS-induced TNF-alpha factor NM004862 1.9 proinflammatory cytokine 15 COL7A1 collagen, type VII, alpha 1 NM000094 1.85 epithelial adhesion complex 16 HRMT1L2 HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2 NM001536 1.84 catalyzes protein methyl-transferase modification 17 CXCL13 small inducible cytokine B subfamily, member 13 NM006419 1.82 migration of B lymphocytes 18 PLAU plasminogen activator, urokinase NM002658 1.78 serine protease 19 CDC37 cell division cycle 37 NM007065 1.77 cell-cycle regulation 20 Pax paxillin NM002859 1.74 cell adhesion of the extracellular matrix a) High/low ratio; the ratio of the quantitative value of the gene expression in tumors of the high SUV group to that in tumors of the low SUV group.

Shigeto Ueda et al.

BMC Cancer 8 (7), 22 Dec 2008

Table 3 Comparision of clinicopathological features of patients and immunohistochemical results of biomarkers between the low SUV group and the high SUV group in 47 cases of node-negative breast cancer Parameters High SUV group (n = 27) Low SUV group (n = 20) p-value SUV Ave± SD 7.8± 3.4 2.2± 1.0 <0.0001 Age Ave± SD 55.6± 10.1 53.2± 10.0 0.42 Tumor size Ave± SD 3.1± 2.1 2.4± 2.9 0.33 Nuclear grade 1 and 2 8 15 0.004 3 19 5 ER <10% 11 3 0.06 10% ≦ 16 17 HER2 0,1+,2+ (FISH-) 20 18 0.17 3+ or FISH+ 7 2 CENP-F Positive 20 9 0.04 Negative 7 11 n-CDC6 Positive 13 10 0.9 Negative 10 10 c-CDC6 Positive 9 7 0.9 Negative 18 13 Ki67 Positive 25 12 0.02 Negative 2 8 p53 Positive 9 2 0.06 Negative 18 18 Molecular subtypes Luminal A 16 17 0.05 HER2 7 2 Triple negative 4 1 Abbreviations; SUV, Standardized uptake value; ER, Estrogen receptor; HER2, c-erbB2; FISH, Fluorescence in situ hybridization; SD, standard deviation; CENP-F, Centromere protein-F; SUV, Standardized uptake value; n-CDC6, nuclear staining of Cell devision cycle 6; c-CDC6, cytoplasmic staining of Cell devision cycle 6

Shigeto Ueda et al.

BMC Cancer 8 (7), 22 Dec 2008

Immunohistochemistry with anti-human antibodies against centromere protein F (CENP-F) (ab90, 1/200 dilution; Abcam, Cambridge, MA), phosphorylated-CDC6-S54 (CDC6) (AP3058a, 1/200 dilution; Abgent, San Diego, CA), Ki67 (clone: MIB1, ready-to-use, Dako, Glostrup, Denmark), and p53 (clone: DO-7, 1/200 dilution, Dako) was performed by the streptavidin-biotin-peroxidase complex method or the EnVision (Dako) method.

Shigeto Ueda et al.

BMC Cancer 8 (7), 22 Dec 2008

Abbreviations (CENP-F): centromere protein F; (SUV): standardized uptake value; (FDG PET/CT): 18F-fluorodeoxyglucose positron emissiontomography/computed tomography; (FDG): 18 F-fluorodeoxyglucose; (PST): primary systemic therapy; (ROI): region of interest; (TMA): Tissue microarray; (nCDC6): nuclear CDC6; and (cCDC6): cytoplasmic CDC6.

Shigeto Ueda et al.

BMC Cancer 8 (7), 22 Dec 2008

4 further examples >>
Publications
 

Prognostic relevance of Centromere protein H expression in esophageal carcinoma

Xian-Zhi Guo et al.

BMC Cancer , 13 Aug 2008

Determination of the binding constants of the centromere protein Cbf1 to all 16 centromere DNAs of Saccharomyces cerevisiae

Gerhard Wieland et al.

Nucleic Acids Research , 01 Mar 2001

Expression of centromere protein F (CENP-F) associated with higher FDG uptake on PET/CT, detected by cDNA microarray, predicts high-risk patients with primary breast cancer

Shigeto Ueda et al.

BMC Cancer , 22 Dec 2008

All 16 centromere DNAs from Saccharomyces cerevisiae show DNA curvature.: All 16 centromere DNA regions of Saccharomyces cerevisiae including 90 bp framing sequences on either side were cloned. These 300 bp long centromere regions were analysed by native polyacrylamide gel electrophoresis and found to display a reduced mobility indicative of DNA curvature. The degree of curvature is centromere dependent. The experimental data were confirmed by computer analysis of the 3-dimensional structure of the CEN DNAs. Altogether these data provide further evidence for a model for budding yeast centromeres in which CEN DNA structure could be important for the assembly, activity and/or regulation of the centromere protein-DNA complex.

T Bechert et al.

Nucleic Acids Research , 15 Mar 1999

Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome: ... showed a pattern of centromere and spindle microtubule staining resembling that of the chromosomal passenger protein complex. By using a ...

Beatriz Rodríguez-Bayona et al.

Journal of Autoimmune Diseases , 12 Jan 2007

Cpf1 protein induced bending of yeast centromere DNA element I.: The centromere complex is a multicomponent structure essential for faithful chromosome transmission. Here we show that the S. cerevisiae centromere protein Cpf1 bends centromere ...

R K Niedenthal et al.

Nucleic Acids Research , 11 Oct 1993

CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether: The mitotic kinesin centromere protein E (CENP-E) is an ...

Yumi Kim et al.

The Journal of Cell Biology , 05 May 2008

Creation and characterization of temperature-sensitive CENP-C mutants in vertebrate cells: ... conserved centromere protein that is thought to be ...

Tatsuo Fukagawa et al.

Nucleic Acids Research , 15 Sep 2001

Molecular cloning and sequence analysis of hamster CENP-A cDNA: Background The centromere is a specialized locus that mediates chromosome movement during mitosis and meiosis. This chromosomal domain comprises a uniquely packaged form of heterochromatin that acts as a nucleus for the assembly of the kinetochore a trilaminar proteinaceous structure on the surface of each chromatid at the primary constriction. Kinetochores mediate interactions with the spindle fibers of the mitotic apparatus. Centromere protein A (CENP-A) is a histone ...

Javier Figueroa et al.

BMC Genomics , 03 May 2002

Differential Gene Expression in Normal Human Mammary Epithelial Cells Treated with Malathion Monitored by DNA Microarrays: ... activator ( PLAT ), centromere protein F ( CPF ), replication ...

Maureen R. Gwinn et al.

Environmental Health Perspectives , 01 Aug 2005

1 further publication >>