cocktails

The necessity for AO cocktails to induce efficient exon removal was observed with 2 different chemistries, 2'-O-methyl modified bases on a phosphorothioate backbone and phosphorodiamidate morpholino oligomers.

Abbie M Adams et al.

BMC Molecular Biology 8 (7), 02 Jul 2007

In this report, we describe optimization and excision of recalcitrant dystrophin exons from the mature mRNA using AO cocktails for enhanced efficiency and/or specificity.

Abbie M Adams et al.

BMC Molecular Biology 8 (7), 02 Jul 2007

Several different AO cocktails were then evaluated and found to induce some exon 20 skipping, although consistent variation in efficiency between the different preparations was evident (Figures 1b–f ).

Abbie M Adams et al.

BMC Molecular Biology 8 (7), 02 Jul 2007

It would appear that combinations of the "best" AOs may not necessarily lead to the optimal AO cocktails, at least for dystrophin exon 20, currently classified as a Type 4 exon.

Abbie M Adams et al.

BMC Molecular Biology 8 (7), 02 Jul 2007

However, while some AO cocktails were found to be essentially inactive, other combinations were very efficient at inducing exon 65 skipping.

Abbie M Adams et al.

BMC Molecular Biology 8 (7), 02 Jul 2007

Antisense oligonucleotide induced exon skipping and the dystrophin gene transcript: cocktails and chemistries

Abbie M Adams et al.

BMC Molecular Biology , 02 Jul 2007

Chemical Cocktails

David C. Holzman

Environmental Health Perspectives , 01 Mar 2000

Ten Years of Mixing Cocktails: A Review of Combination Effects of Endocrine-Disrupting Chemicals

Andreas Kortenkamp

Environmental Health Perspectives , 01 Dec 2007

Generation of clinical grade dendritic cells with capacity to produce biologically active IL-12p70: ... new maturation cocktails allowing DCs to produce ...

Anke Zobywalski et al.

Journal of Translational Medicine , 12 Apr 2007

dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference: ... RNA (siRNA) cocktails. The software simulates ...

Yuki Naito et al.

Nucleic Acids Research , 01 Jul 2005

An insight into the sialome of the oriental rat flea, Xenopsylla cheopis (Rots): ... creation of salivary cocktails of blood feeding ...

John F Andersen et al.

BMC Genomics , 16 Apr 2007

Assessment of the feasibility of exon 45–55 multiexon skipping for duchenne muscular dystrophy: ... using various AON cocktails. Results In all ...

Laura van Vliet et al.

BMC Medical Genetics , 01 Dec 2008

Use of folding modulators to improve heterologous protein production in Escherichia coli: ... coli , and particularly cocktails thereof, driven largely ...

Olga Kolaj et al.

Microbial Cell Factories , 27 Jan 2009

Comparative secretome analyses of two Trichoderma reesei RUT-C30 and CL847 hypersecretory strains: ... between cellulase cocktails. The results ...

Isabelle Herpoël-Gimbert et al.

Biotechnology for Biofuels , 23 Dec 2008

Induction of revertant fibres in the mdx mouse using antisense oligonucleotides: ... the feasibility of AO cocktails to by-pass dystrophin ...

Abbie M Fall et al.

Genetic Vaccines and Therapy , 24 May 2006