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Microbial Collagenase definition: A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
Matrix Metalloproteinase 1 definition: A member of the metalloproteinase family of enzymes that is principally responsible for cleaving FIBRILLAR COLLAGEN. It can degrade interstitial collagens, types I, II and III.
Matrix Metalloproteinase-1 definition: Encoded by human MMP1 Gene (M10A Peptidase Family), 469-aa 54-kDa (precursor) secreted zinc- and calcium-binding Matrix Metalloproteinase-1 contains a hemopexin-like domain, an N-terminal catalytic domain, and a C-terminal substrate- and TIMP-binding domain. MMP1 undergoes autolytic cleavage to major forms 27-kDa (inactive) and 22-kDa (a collagenase activator). MMP1 preferentially cleaves interstitial collagens types I, II, and III at one site in the triple helical domain. MMP1 also cleaves collagens types VII and X and alpha-macroglobulins. (NCI)
Collagenases definition: Enzymes that catalyze the degradation of collagen by acting on the peptide bonds. EC 3.4.24.-.
collagenase definition: enzymes that catalyze the degradation of collagen by acting on the peptide bonds.
Collagenase definition: Collagenases are enzymes that degrade collagen fibers. These enzymes play an important role in connective tissue metabolism and are produced by specific cells involved in both repair and remodeling processes.
Matrix Metalloproteinase 3 definition: An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)
Matrix Metalloproteinase 3 definition: This protein is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. (from LocusLink)
Matrix Metalloproteinase 9 definition: An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.
Matrix Metalloproteinase-9 definition: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This enzyme degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (from LocusLink)
16 further definitions >>
Examples
 

Objective: This study focuses on the growth-promoting and migration-enhancing role that Clostridial collagenase plays in vitro and in vivo.

Kathleen N. Riley et al.

Journal of Burns and Wounds 4 (7), 17 May 2005

Methods: For in vitro studies, biosynthesized extracellular matrices were treated with purified Clostridial collagenase, nonspecific proteases, or buffer controls.

Kathleen N. Riley et al.

Journal of Burns and Wounds 4 (7), 17 May 2005

Keratinocytes were subsequently plated upon these matrices in the presence or absence of Clostridial collagenase and/or heparin-binding epidermal-like growth factor, and cell proliferation and migration were quantified.

Kathleen N. Riley et al.

Journal of Burns and Wounds 4 (7), 17 May 2005

To examine the effects of Clostridial collagenase in vivo, we performed a double-blind study of full-thickness wounds on the backs of Yucatan Micropigs, testing the effects of purified Clostridial collagenase, Regranex (PDGF-BB), and Solosite (carboxymethyl cellulose) on wound healing.

Kathleen N. Riley et al.

Journal of Burns and Wounds 4 (7), 17 May 2005

Results: In vitro studies: Matrix pretreatment with Clostridial collagenase stimulates a 2-fold increase in proliferation and postinjury migration; when Clostridial collagenase and/or heparin-binding epidermal-like growth factor are added to the growth media, there is an additional doubling of growth and migration, yielding approximately 5-fold enhancement of keratinocyte proliferation and migration.

Kathleen N. Riley et al.

Journal of Burns and Wounds 4 (7), 17 May 2005

76 further examples >>
Publications
 

Collagenase Promotes the Cellular Responses to Injury and Wound Healing In Vivo

Kathleen N. Riley et al.

Journal of Burns and Wounds , 17 May 2005

Tissue localization of collagenase and leucine aminopeptidase in the bovine filarial parasite Setaria cervi

Daya R Pokharel et al.

Filaria Journal , 22 May 2006

Regulation of collagenase gene expression by IL-1 beta requires transcriptional and post-transcriptional mechanisms.

M P Vincenti et al.

Nucleic Acids Research , 11 Nov 1994

Differential regulation of collagenase gene expression by retinoic acid receptors--alpha, beta and gamma.

L Pan et al.

Nucleic Acids Research , 25 Jun 1992

In vitro and in vivo Expression of Interstitial Collagenase/MMP-1 by Human Mast Cells

Nick Di Girolamo et al.

Developmental Immunology , 2000

NIM811, a nonimmunosuppressive cyclosporine analogue, suppresses collagen production and enhances collagenase activity in hepatic stellate cells

Motoyuki Kohjima et al.

Liver International , 01 Nov 2007

Collagen and Collagenase

Madeline K. Keech

The Yale Journal of Biology and Medicine , 01 Feb 1954

Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis

Jennifer M Milner et al.

Arthritis Research & Therapy , 2006

The role of collagenase in emphysema

Robert Foronjy et al.

Respiratory Research , 2001

Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production

Christina Alexandra Manacu et al.

Arthritis Research & Therapy , 2005

71 further publications >>