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Nitric Oxide Synthase 3 definition: Expressed in platelets and endothelia by human NOS3 Gene (NOS Family), conserved constitutive 1202-aa 133-kDa Nitric Oxide Synthase 3 is a calcium/calmodulin stimulated homodimer stabilized by BH4 that contains a flavodoxin-like domain, binds FAD and FMN cofactors, and synthesizes NO from L-arginine. Endothelial NO appears to exert EDRF activity that inhibits vascular smooth muscle contraction through a cGMP pathway. NOS3 activity also inhibits platelet aggregation and mediates VEGF-induced angiogenesis. Vascular shear stress activates endothelial PI3K and AKT, which directly phosphorylates (Ser1177) and enhances NOS3 activity and calcium sensitivity. Potentially influencing the control of energy balance, NO also triggers cGMP-dependent mitochondrial biogenesis mediated by induction of the master regulator PPARGC1. (NCI)
Nitric Oxide Synthase Type I definition: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.
Nitric Oxide Synthase Type III definition: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
Nitric Oxide Synthase 1 definition: Encoded as 4 alternative isoforms by human NOS1 Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 1 binds FAD and FMN cofactors, contains a PDZ/DHR and a flavodoxin-like domain, requires BH4 which may stabilize the dimer, and synthesizes nitric oxide messenger from L-arginine. Neuronal NO displays neurotransmitter properties. N-truncated Isoform 3 possesses enzymatic activity. C-truncated isoform 4 is produced by frameshift exon insertion. NOS1 may interact with DLG4 and forms a ternary complex with CAPON and RASD1. NOS1 is localized beneath the sarcolemma in fast-twitch skeletal muscle fibers by associating with the dystrophin glycoprotein complex. The N-terminal PDZ domain of the neuronal NOS1 may participate in protein-protein interaction and target nNos to synaptic membranes. PIN inhibition may prevent NOS1 dimerization. (NCI)
constitutive hydrogen:glucose symporter activity definition: Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constituitive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport]
constitutive secretory pathway definition: A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space. [GOC:mah, ISBN:0716731363]
constitutive protein ectodomain proteolysis definition: The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands. [PMID:12714508]
konstitutive Regel definition: [1] Linguistik, speziell Sprechakttheorie: Regeln, die die Voraussetzung dafür sind, dass ein Vorgang als Vollzug einer bestimmten, beabsichtigten Handlung gilt.