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Translation
 
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1 word
corepressor corépresseur
 
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Definition
 
enEnglish
DR1-Associated Protein 1 definition: Encoded by human DRAP1 Gene, DR1-Associated Protein 1 is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. DR1 interacts with the TATA-binding protein (TBP) of TFIID and prevents formation of an active transcription complex by precluding TFIIA and/or TFIIB entry into the preinitiation complex. DRAP1 and DR1 interaction is required for corepressor function and stabilizes the TBP-DR1-DNA complex. DRAP1 protein contains a histone fold motif at the N terminus and a proline-rich region at the C terminus. The binding of DRAP1 to DR1 is dependent on the histone fold motif present in each protein. DRAP1 expression facilitates the maintenance of a differentiated state by silencing specific genes. (NCI)
Sin3 Histone Deacetylase and Corepressor Complex definition: A multisubunit enzyme complex that regulates GENETIC TRANSCRIPTION by deacetylating the HISTONE residues of NUCLEOSOMES.
transcription corepressor activity definition: The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself. [GOC:ma]
DRAP1 Gene definition: This gene plays a role in repression of transcription.
NCOR1 Gene definition: This gene is involved in chromatin remodeling and repression of transcription.
NCOR2 Gene definition: This gene plays a role in repression of transcription. It is also involved in chromatin remodeling.
Transcription Coregulator Gene definition: RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. A second group of cofactors includes PC1, PC2, and PC3, which have a strong positive influence on transcription. A third group of factors suppress transcription. The combined action of general and gene-specific regulators encoded by transcription coactivator genes determines appropriate gene expression. (NCI)
Transcription Repressor/Corepressor Gene definition: RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. Transcription Corepressor Genes encode a group of transcriptional repressor/co-repressor factors that suppress transcription by binding to the operator. (NCI)
Transcription Repressor/Corepressor definition: Transcription Repressor/Corepressor Gene encodes Transcriptional Repressor/Corepressor, proteins that can regulate transcription by binding to the operator and causing repression. (from Glick: Glossary of Biochemistry and Molecular Biology)
Nuclear Receptor Co-Repressor 1 definition: A nuclear protein that regulates the expression of genes involved in a diverse array of processes related to metabolism and reproduction. The protein contains three nuclear receptor interaction domains and three repressor domains and is closely-related in structure to NUCLEAR RECEPTOR CO-REPRESSOR 2.
6 further definitions >>
frFrench
corépresseur definition: Molécule qui déclenche la répression de la transcription de gènes spécifiques en se fixant au répresseur.
 
Publications
 

Corepressor/coactivator paradox: potential constitutive coactivation by corepressor splice variants

Xianwang Meng et al.

Nuclear Receptor Signaling , 30 Oct 2006

SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus

K. M. Viiri et al.

Nucleic Acids Research , 2006

ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases

Jorge Lopez-Garcia et al.

Nucleic Acids Research , 01 Dec 2006

The human SIN3B corepressor forms a nucleolar complex with leukemia-associated ETO homologues

Rakesh Singh Dhanda et al.

BMC Molecular Biology , 19 Jan 2008

Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1

Chiung-Wen Chang et al.

BMC Molecular Biology , 01 Jul 2008

Cell cycle-regulated repression of B-myb transcription: cooperation of an E2F site with a contiguous corepressor element.

N Liu et al.

Nucleic Acids Research , 01 Aug 1996

The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70.

G E Muscat et al.

Nucleic Acids Research , 15 Jun 1998

Role of the Transcriptional Corepressor Bcor in Embryonic Stem Cell Differentiation and Early Embryonic Development

Joseph Alan Wamstad et al.

PLoS ONE , 30 Jul 2008

Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors.

M Downes et al.

Nucleic Acids Research , 15 Nov 1996

Differential regulation of NAB corepressor genes in Schwann cells

Rajini Srinivasan et al.

BMC Molecular Biology , 20 Dec 2007

35 further publications >>