dict.md logo
Choose languages of interest
0 translations
Histone Deacetylases definition: Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
Histone Deacetylase definition: Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the histone deacetylases. There are at least 2 classes of HDACs, class I consisting of proteins homologous to yeast Rpd3 (e.g., HDAC1, HDAC2, and HDAC3) and class II consisting of proteins homologous to yeast Hda1 (e.g., HDAC4 and HDAC6). (from OMIM)
Group III Histone Deacetylases definition: A subclass of histone deacetylases that are NAD-dependent. Several members of the SIRTUINS family are included in this subclass.

Sirtuins: Sir2-related NAD-dependent protein deacetylases

Brian J North et al.

Genome Biology , 2004

Histone deacetylases in fungi: novel members, new facts

Patrick Trojer et al.

Nucleic Acids Research , 15 Jul 2003

Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases

Olivier Vaute et al.

Nucleic Acids Research , 15 Jan 2002

The Flavoring Agent Dihydrocoumarin Reverses Epigenetic Silencing and Inhibits Sirtuin Deacetylases

Andrew J Olaharski et al.

PLoS Genetics , 01 Dec 2005

The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications

Philipp Jahnke et al.

Nucleic Acids Research , 01 Nov 2008

Substitution as a Mechanism for Genetic Robustness: The Duplicated Deacetylases Hst1p and Sir2p in Saccharomyces cerevisiae

Meleah A Hickman et al.

PLoS Genetics , 01 Aug 2007

Histone Deacetylases Control Neurogenesis in Embryonic Brain by Inhibition of BMP2/4 Signaling

Maya Shakèd et al.

PLoS ONE , 16 Jul 2008

Histone deacetylases, acetoin utilization proteins and acetylpolyamine amidohydrolases are members of an ancient protein superfamily.

D D Leipe et al.

Nucleic Acids Research , 15 Sep 1997

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer

Florian R Fritzsche et al.

BMC Cancer , 19 Dec 2008

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

Yan Ling et al.

Nucleic Acids Research , 2004

61 further publications >>