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Dopa Decarboxylase definition: One of the AROMATIC-L-AMINO-ACID DECARBOXYLASES, this enzyme is responsible for the conversion of dopa to dopamine. It is of clinical importance in the treatment of Parkinson's disease. EC 4.1.1.28.
Carboxy-Lyases definition: Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.
decarboxylase definition: enzymes which catalyze the nonhydrolytic removal of carbon dioxide from carboxylic acids.
Glutamate Decarboxylase definition: A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
Histidine Decarboxylase definition: An enzyme that catalyzes the decarboxylation of histidine to histamine and carbon dioxide. It requires pyridoxal phosphate in animal tissues, but not in microorganisms. EC 4.1.1.22.
Ornithine Decarboxylase definition: A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine. EC 4.1.1.17.
Orotidine-5'-Phosphate Decarboxylase definition: Orotidine-5'-phosphate carboxy-lyase. Catalyzes the decarboxylation of orotidylic acid to yield uridylic acid in the final step of the pyrimidine nucleotide biosynthesis pathway. EC 4.1.1.23.
Pyruvate Decarboxylase definition: Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 4.1.1.1.
pyruvate decarboxylase definition: also another name for EC 1.2.4.1, PYRUVATE DEHYDROGENASE, do not confuse.
Adenosylmethionine Decarboxylase definition: An enzyme that catalyzes the decarboxylation of S-adenosyl-L-methionine to yield 5'-deoxy-(5'-),3-aminopropyl-(1), methylsulfonium salt. It is one of the enzymes responsible for the synthesis of spermidine from putrescine. EC 4.1.1.50.
8 further definitions >>
Publications
 

Structure of the gene for human uroporphyrinogen decarboxylase.

M Romana et al.

Nucleic Acids Research , 25 Sep 1987

The regulation of histidine decarboxylase gene expression.

M. Höcker et al.

The Yale Journal of Biology and Medicine , 1996

Characterization of the Entamoeba histolytica Ornithine Decarboxylase-Like Enzyme

Anupam Jhingran et al.

PLoS Neglected Tropical Diseases , 02 Jan 2008

Induction of ornithine decarboxylase activity by growth and differentiation factors in FRTL-5 cells.

M. C. Eggo et al.

The Yale Journal of Biology and Medicine , 1989

Chloroform induction of ornithine decarboxylase activity in rats.

R E Savage et al.

Environmental Health Perspectives , 01 Dec 1982

Nucleotide sequence of the pyruvate decarboxylase gene from Zymomonas mobilis.

A D Neale et al.

Nucleic Acids Research , 25 Feb 1987

Regulation of ornithine decarboxylase gene expression by the Wilms' tumor suppressor WT1.

J A Moshier et al.

Nucleic Acids Research , 15 Mar 1996

Transcription factor Sp3 antagonizes activation of the ornithine decarboxylase promoter by Sp1.

A P Kumar et al.

Nucleic Acids Research , 15 May 1997

Analysis of the primary structure and promoter function of a pyruvate decarboxylase gene (PDC1) from Saccharomyces cerevisiae.

E Kellermann et al.

Nucleic Acids Research , 25 Nov 1986

Sequence and expression of the Cc gene, a member of the dopa decarboxylase gene cluster of Drosophila: possible translational regulation.

D D Eveleth et al.

Nucleic Acids Research , 11 Aug 1986

125 further publications >>