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Definition
 
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Complementarity Determining Regions definition: Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
Immunoglobulin Hypervariable Region definition: Within the variable domain of an antibody molecule are three regions called hypervariable regions, areas of high sequence diversity. These regions form the surfaces that are responsible for antigen binding interactions. Also known as complementarity determining region or hypervariable loop.
Sex-Determining Region Y Protein definition: Sex Determining Region Y Protein (204 aa, 24 kDa) is a development protein that is encoded by the human SRY gene and is involved in testis development and may be involved in transcription.
Sex-Determining Region Y Protein definition: A transcription factor that plays an essential role in the development of the TESTES. It is encoded by a gene on the Y chromosome and contains a specific HMG-BOX DOMAIN that is found within members of the SOX family of transcription factors.
Genes, sry definition: The primary testis-determining gene in mammalians, located on the Y CHROMOSOME. It codes for a high mobility group box transcription factor (TRANSCRIPTION FACTORS) which initiates the development of the TESTES from the embryonic GONADS.
SOX18 Gene definition: This gene plays a role in transcriptional regulation.
SOX2 Gene definition: This gene is involved in embryonic development and in the determination of cell fate.
SOX3 Gene definition: This gene is involved in neuronal differentiation.
SOX9 Gene definition: This gene plays roles in transcription, osteogenesis, chondrogenesis and testis development.
SRY Gene definition: This gene is involved in testis development and may be involved in transcription.
7 further definitions >>
Publications
 

A photoinduced cleavage of DNA useful for determining T residues.

A Simoncsits et al.

Nucleic Acids Research , 20 Dec 1982

Determining gene expression on a single pair of microarrays

Robert W Reid et al.

BMC Bioinformatics , 21 Nov 2008

Factors determining the outcome of children hospitalized with severe pneumonia

Karalanglin Tiewsoh et al.

BMC Pediatrics , 23 Feb 2009

Convergent Evolution of Chromosomal Sex-Determining Regions in the Animal and Fungal Kingdoms

James A Fraser et al.

PLoS Biology , 01 Dec 2004

Predicting specificity-determining residues in two large eukaryotic transcription factor families

Jason E. Donald et al.

Nucleic Acids Research , 2005

The Design of a Chemical Virtual Instrument Based on LabVIEW for Determining Temperatures and Pressures

Wen-Bin Wang et al.

Journal of Automated Methods & Management in Chemistry , 2007

Mapping of five candidate sex-determining loci in rainbow trout ( Oncorhynchus mykiss )

Mahmoud A Alfaqih et al.

BMC Genetics , 15 Jan 2009

Isolation of a sequence which maps close to the human sex determining gene.

C A Pritchard et al.

Nucleic Acids Research , 11 Aug 1987

Determining Physical Constraints in Transcriptional Initiation Complexes Using DNA Sequence Analysis

Ryan K. Shultzaberger et al.

PLoS ONE , 21 Nov 2007

Determining significance of pairwise co-occurrences of events in bursty sequences

Niina Haiminen et al.

BMC Bioinformatics , 08 Aug 2008

1608 further publications >>