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MADD Protein definition: Encoded by MADD Gene, MADD Protein Isoforms A-G are expressed in adult testis, ovary, brain, heart, and fetal brain and kidney. The 1588-amino acid 176.6-kD isoform D is full-length. Most variants involve 2-4 stretches of 18-43 amino acids in the central region. Isoforms F and G have a different C-terminus. Containing a C-terminal death domain, RGD motif, and a leucine zipper-like motif, SER- and LEU-rich membrane-bound MADD adaptor protein interacts with TNFR1 death domain to propagate apoptotic signaling. MADD can activate ERK2 and JNK1 MAP kinases and induce phosphorylation of Phospholipase A2. MADD appears to link TNFR1 with MAP kinase activation and arachidonic acid release. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Matriptase definition: This protein is an epithelial-derived, integral membrane serine protease. It forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. (from LocusLink)
Matriptase definition: Expressed in prostate, kidney, lung, small intestine, stomach, colon, placenta, spleen, liver, leukocytes, and thymus, human ST14 Gene (Peptidase S1 Family) encodes an 855-aa 95-kD membrane-associated serine protease, Matriptase. ST14 contains an N-region integrin-binding site, N-glycosylation sites, tandem LDLR class A cysteine repeats, CUB domains, a putative proteolytic activation site, a C-terminal trypsin-like serine protease region, an S1 pocket, an S2 subsite, and an S4 cavity. Protease specificity involves additional cleavage site residues. Complexed with 40-kD SPINT1, a Kunitz-type inhibitor, ST14 is activated by sphingosine 1-phosphate, degrades extracellular matrix, and cleaves/activates HGF and urokinase plasminogen activator. ST14 may play a role in cancer invasion and metastasis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
DAB2 Gene definition: This gene is involved in the regulation of cell proliferation.
Disabled Homolog 2 Protein definition: Encoded by human tumor suppressor DAB2 Gene, Disabled Homolog 2 Protein is expressed in ovarian, breast, and lung epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, placenta, brainstem, heart, and small intestine. The 770-amino acid 82.5-kD predicted protein has 83% identity with mouse p96 protein, a putative mitogen-responsive phosphoprotein; strongest homology exists in the N-terminal PTB/PID domain. Potentially phosphorylated, DAB2 is a putative component of the CSF-1 cell proliferation signal transduction pathway. (from LocusLink, Swiss-Prot, OMIM, and NCI)
MADD Gene definition: This proto-oncogene is involved in the regulation of apoptosis and propagates cell death via signal transduction.