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Dimethyl Sulfate definition: An odorless, corrosive, oily liquid with an onion-like odor that emits toxic fumes upon heating. Dimethyl sulfate is used in industry as a methylating agent in the manufacture of many organic chemicals. Inhalation exposure to its vapors is highly irritating to the eyes and lungs and may cause damage to the liver, kidney, heart and central nervous system, while dermal contact causes severe blistering. It is a possible mutagen and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)

Repair of cyclobutane pyrimidine dimers or dimethylsulfate damage in DNA is identical in normal or telomerase-immortalized human skin fibroblasts

Steven E. Bates et al.

Nucleic Acids Research , 2005

Footprint analysis of the bsp RI DNA methyltransferase-DNA interaction.: ... Footprinting with dimethylsulfate detected major groove ...

C Finta et al.

Nucleic Acids Research , 15 Jul 1997

Triplex formation by oligonucleotides containing novel deoxycytidine derivatives.: ... spectroscopy and dimethylsulfate alkylation experiments. ...

C Y Huang et al.

Nucleic Acids Research , 01 Jul 1996

Binding of tRNA alters the chemical accessibility of nucleotides within the large ribosomal RNAs of E. coli ribosomes.: ... modified with dimethylsulfate (DMS) in the presence ...

N Meier et al.

Nucleic Acids Research , 10 Feb 1984

A Pyrococcus homolog of the leucine-responsive regulatory protein, LrpA, inhibits transcription by abrogating RNA polymerase recruitment: ... was inferred from dimethylsulfate methylation ...

Isabell Dahlke et al.

Nucleic Acids Research , 01 Feb 2002

Anthramycin inhibition of restriction endonuclease cleavage and its use as a reversible blocking agent in DNA constructions.: ... residues at N-3 by dimethylsulfate is reduced. The ...

W Sumner et al.

Nucleic Acids Research , 11 May 1981

Interactions of RNA polymerase and the cyclic AMP receptor protein on DNA of the E. coli galactose operon.: ... action of DNAase and dimethylsulfate. Some of the ...

T Taniguchi et al.

Nucleic Acids Research , 11 Aug 1983

Solution structure of human U1 snRNA. Derivation of a possible three-dimensional model.: ... chemical probes (dimethylsulfate, carbodiimide, ...

A Krol et al.

Nucleic Acids Research , 11 Jul 1990

On the flexible interaction of yeast factor tau with the bipartite promoter of tRNA genes.: ... intervening sequence. Dimethylsulfate protection analysis of ...

S Camier et al.

Nucleic Acids Research , 11 Aug 1990

Biological properties of imidazole ring-opened N7-methylguanine in M13mp18 phage DNA.: ... vitro in phage DNA by dimethylsulfate (DMS) methylation and ...

B Tudek et al.

Nucleic Acids Research , 25 Jun 1992

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